A spectroscopic and molecular modeling studies of the inclusion complexes of orciprenaline and terbutaline drugs with native and modified cyclodextrins

被引：6
|
作者：
Venkatesh, G. [1 ]
Thulasidhasan, J. [1 ]
Rajendiran, N. [1 ]
机构：
[1] Annamalai Univ, Dept Chem, Chidambaram 608002, Tamil Nadu, India
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2014年 / 78卷 / 1-4期
关键词：
Orciprenaline; Terbutaline; Excimer emission; Modified CD; Molecular modeling; PM3; method; BETA-CYCLODEXTRIN; SPECTRAL CHARACTERISTICS; DUAL FLUORESCENCE; EXCIMER FORMATION; DIFFERENT SOLVENTS; AQUEOUS-SOLUTIONS; THERMODYNAMICS; ENCAPSULATION; THERAPY; LABOR;
D O I：
10.1007/s10847-013-0291-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The inclusion complexation behavior of orciprenaline (ORC) and terbutaline (TER) with alpha-CD, beta-CD, HP-alpha-CD and HP-beta-CD are examined by absorption, fluorescence, life time and molecular modeling methods. ORC and TER forms 1:1 (CD/drug) inclusion complexes in lower CD concentrations and 1:2 (CD/drug) inclusion complexes with higher CD concentrations. The inclusion of both drugs with HP-CDs was stronger than that of native CDs. Both drugs exhibit dual emission (excimer) in the CD solution, whereas in water single emission is seen. The hydrogen bonding and van der Waals interaction between the drugs and the CD plays an important role in the inclusion complexes. Computational results show the side chain of the drugs encapsulated in the CD cavity. The molecular modeling results by PM3 were in good agreement with the experimental results.
引用
收藏
页码：225 / 237
页数：13
相关论文
共 50 条
  • [1] A spectroscopic and molecular modeling studies of the inclusion complexes of orciprenaline and terbutaline drugs with native and modified cyclodextrins
    G. Venkatesh
    J. Thulasidhasan
    N. Rajendiran
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2014, 78 : 225 - 237
  • [2] Spectral and Molecular Modeling Studies on Hydroxybenzaldehydes with Native and Modified Cyclodextrins
    M. Jude Jenita
    T. Mohandass
    N. Rajendiran
    Journal of Fluorescence, 2014, 24 : 695 - 707
  • [3] Spectral and Molecular Modeling Studies on Hydroxybenzaldehydes with Native and Modified Cyclodextrins
    Jenita, M. Jude
    Mohandass, T.
    Rajendiran, N.
    JOURNAL OF FLUORESCENCE, 2014, 24 (03) : 695 - 707
  • [4] NMR spectroscopic characterization of inclusion complexes of hydroxy-substituted naphthalenes with native and modified β-cyclodextrins
    Sueishi, Yoshimi
    Inazumi, Naoya
    Hanaya, Tadashi
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2009, 64 (1-2) : 135 - 141
  • [5] NMR spectroscopic characterization of inclusion complexes of hydroxy-substituted naphthalenes with native and modified β-cyclodextrins
    Yoshimi Sueishi
    Naoya Inazumi
    Tadashi Hanaya
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2009, 64 : 135 - 141
  • [6] Spectroscopic studies on inclusion complexes of MAQO and MPQO with cyclodextrins
    Lu, RH
    Wang, HQ
    Tong, LH
    MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 1999, 10 (1-2): : 7 - 11
  • [7] Spectroscopic studies on inclusion complexes of MAQO and MPQO with cyclodextrins
    Lu, Runhua
    Wang, Hanqing
    Tong, Linhui
    Materials Science and Engineering C, 1999, 10 (1-2): : 7 - 11
  • [8] Spectroscopic studies on molecular recognition of modified cyclodextrins
    Liu, Y
    Han, BH
    Zhang, HY
    CURRENT ORGANIC CHEMISTRY, 2004, 8 (01) : 35 - 46
  • [9] Mass spectrometry and molecular modeling studies on the inclusion complexes between α,β-cyclodextrins and simvastatin
    Wen, XH
    Liu, ZY
    Zhu, TQ
    CHEMICAL PHYSICS LETTERS, 2005, 405 (1-3) : 114 - 117
  • [10] Structural Studies of Piperine Inclusion Complexes in Native and Derivative β-Cyclodextrins
    Christoforides, Elias
    Andreou, Athena
    Papaioannou, Andreas
    Bethanis, Kostas
    BIOMOLECULES, 2022, 12 (12)
12345