Sintering behavior and biocompatibility of a low temperature co-fired ceramic for microfluidic biosensors

被引：5

作者：

Luo, Jin ^{[1
,2
]}

Eitel, Richard ^{[3
]}

机构：

[1] Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA

[2] Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Sch Mat Sci & Engn, Beijing, Peoples R China

[3] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA

来源：

INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY | 2017年 / 14卷 / 02期

关键词：

bioceramics; layered ceramics; low temperature; LTCC; tape casting; BIOACTIVE GLASS; DIELECTRIC-PROPERTIES; BOROSILICATE GLASS; PRACTICAL APPROACH; LTCC APPLICATIONS; VISCOUS-FLOW; DISSOLUTION; TECHNOLOGY; COMPOSITES; DEVICES;

D O I：

10.1111/ijac.12648

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A low temperature co-fired ceramic (LTCC) has been formulated and evaluated for in-vitro microfluidic sensors and cell culture applications. Using a 75/25 vol% glass to alumina ratio, high density was achieved for sintering temperatures <900 degrees C. No toxicity was observed in the leachate medium obtained by soaking LTCC in cell medium for 5 days. The human umbilical vein endothelial cells (HUVECs) also attached on the fibronectin-coated LTCC after 14hours and proliferated after 74hours. On the basis of these results, the current LTCC formulation is a viable candidate for the continued development of LTCC-based microfluidic biosensors.

引用

页码：99 / 107

页数：9

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