Ciclosporin 10 years on: indications and efficacy

被引：53

作者：

Forsythe, Peter ^{[1
]}

Paterson, Sue ^{[2
]}

机构：

[1] Dermatol Referral Serv, Glasgow G51 1RN, Lanark, Scotland

[2] Rutland House Referral Hosp, St Helens WA9 4HU, Merseyside, England

来源：

VETERINARY RECORD | 2014年 / 174卷

关键词：

CANINE ATOPIC-DERMATITIS; CUTANEOUS LUPUS-ERYTHEMATOSUS; RANDOMIZED CONTROLLED TRIAL; ST-JOHNS-WORT; PERIANAL FISTULAS; ANAL FURUNCULOSIS; ORAL CYCLOSPORINE; REACTIVE HISTIOCYTOSIS; SEBACEOUS ADENITIS; A PHARMACOKINETICS;

D O I：

10.1136/vr.102484

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Ciclosporin is a lipophilic cyclic polypeptide with powerful immunosuppressive and immunomodulatory properties that has been used in veterinary medicine for two decades. It is a calcineurin inhibitor whose principal mode of action is to inhibit T cell activation. The drug is principally absorbed from the small intestine and is metabolised in the intestine and liver by the cytochrome P450 enzyme system. Ciclosporin is known to interact with a wide range of pharmacological agents. Numerous studies have demonstrated good efficacy for the management of canine atopic dermatitis and this has been a licensed indication since 2003. In addition to the treatment of atopic dermatitis, it has been used as an aid in the management of numerous other dermatological conditions in animals including perianal fistulation, sebaceous adenitis, pododermatitis, chronic otitis externa and pemphigus foliaceus. This article reviews the mode of action, pharmacokinetics, indications for use and efficacy of ciclosporin in veterinary dermatology.

引用

页码：13 / 21

页数：9

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