A novel analytical method based on the use of a modified dispersive liquid-liquid microextraction (DLLME) technique by ionic liquids has been developed for the first time. This method was applied for the determination of salmeterol in dried blood spot samples from asthmatic patients followed by HPLC system equipped with fluorescence detector. The main novelty of the present work deals with the analysis of salmeterol in dried blood spot with significant advantages with regard to invasive sampling, volume of blood used (<20 mu L), storage and transport of biological materials and requirements for special biohazard arrangements. The effects of significant factors in microextraction procedure including extracting and disperser solvents volume, sample pH and salt contents were investigated. Under optimized conditions, the mean recoveries were higher than 90.0% with linear responses about 1.00-500 ng mL(-1) concentration range. The limit of detection (LOD) was 030 ng mL(-1) in S/N of 3. Intra-day (n = 6) and inter-day (n = 3) assay precision showed relative standard deviation lower than 6.0 and 8.5% for studied drug, respectively. The developed microextraction procedure was simpler and faster than conventional extraction techniques and was omitted hazard organic solvents. Finally, the proposed method is suitable for the analysis of salmeterol in dried blood spots from asthmatic patients for therapeutic drug monitoring purpose. (C) 2013 Elsevier B.V. All rights reserved.
机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Chen Sha
;
Zhong Yi-Sheng
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Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Zhong Yi-Sheng
;
Cheng Shui-Yuan
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Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Cheng Shui-Yuan
;
Qian Tian
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Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Qian Tian
;
Sun Hao
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Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Lehner, AF
;
Hughes, CG
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Hughes, CG
;
Karpiesiuk, W
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Karpiesiuk, W
;
Camargo, FC
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Camargo, FC
;
Harkins, JD
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Harkins, JD
;
Woods, WE
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Woods, WE
;
Bosken, J
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Bosken, J
;
Boyles, J
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Boyles, J
;
Troppmann, A
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Troppmann, A
;
Tobin, T
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Chen Sha
;
Zhong Yi-Sheng
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机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Zhong Yi-Sheng
;
Cheng Shui-Yuan
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h-index: 0
机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Cheng Shui-Yuan
;
Qian Tian
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h-index: 0
机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
Qian Tian
;
Sun Hao
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h-index: 0
机构:
Beijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R ChinaBeijing Univ Technol, Coll Environm & Energy Engn, Beijing, Peoples R China
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Lehner, AF
;
Hughes, CG
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Hughes, CG
;
Karpiesiuk, W
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Karpiesiuk, W
;
Camargo, FC
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Camargo, FC
;
Harkins, JD
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Harkins, JD
;
Woods, WE
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Woods, WE
;
Bosken, J
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Bosken, J
;
Boyles, J
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Boyles, J
;
Troppmann, A
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Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
Troppmann, A
;
Tobin, T
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h-index: 0
机构:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USAUniv Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA