The field of chemistry education research (CER) has matured since 1997 when Bunce and Robinson announced the CER feature in the Journal, and it is time to set out a revised set of guidelines for high-quality manuscripts in CER. Herein, we announce the guidelines, briefly describe them, then use the National Academy of Sciences Discipline-Based Education Research report to identify areas of research and future directions in CER. Our hope is that this stimulates high-quality research manuscripts in areas of need that will drive CER forward, influencing and impacting CER and classroom practices.