Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn - review on current management and outcome

被引:72
作者
Zwiers, Carolien [1 ]
van Kamp, Inge [1 ]
Oepkes, Dick [1 ]
Lopriore, Enrico [2 ]
机构
[1] Leiden Univ, Med Ctr, Dept Obstet, POB 9600, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Pediat, Div Neonatol, Leiden, Netherlands
关键词
Fetal anemia; fetal therapy; hemolytic disease of the fetus and newborn; intrauterine blood transfusion; intravenous immunoglobulin; therapeutic plasma exchange and red cell alloimmunization in pregnancy; RED-CELL ALLOIMMUNIZATION; DOSE INTRAVENOUS IMMUNOGLOBULIN; SEVERE ERYTHROBLASTOSIS-FETALIS; PROCEDURE-RELATED COMPLICATIONS; SEVERE RHESUS ISOIMMUNIZATION; RH D-ALLOIMMUNIZATION; ANTI-D CONCENTRATIONS; INTRAVASCULAR TRANSFUSIONS; GAMMA-GLOBULIN; EXCHANGE-TRANSFUSION;
D O I
10.1080/17474086.2017.1305265
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Hemolytic disease of the fetus and newborn (HDFN) remains a serious pregnancy complication which can lead to severe fetal anemia, hydrops and perinatal death.Areas covered: This review focusses on the current prenatal management, treatment with intrauterine transfusion (IUT) and promising non-invasive treatment options for HDFN.Expert commentary: IUTs are the cornerstone in prenatal management of HDFN and have significantly improved perinatal outcome in the past decades. IUT is now a relatively safe procedure, however the risk of complications is still high when performed early in the second trimester. Non-invasive management using intravenous immunoglobulin may be a safe alternative and requires further investigation.
引用
收藏
页码:337 / 344
页数:8
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