Fetal anemia;
fetal therapy;
hemolytic disease of the fetus and newborn;
intrauterine blood transfusion;
intravenous immunoglobulin;
therapeutic plasma exchange and red cell alloimmunization in pregnancy;
RED-CELL ALLOIMMUNIZATION;
DOSE INTRAVENOUS IMMUNOGLOBULIN;
SEVERE ERYTHROBLASTOSIS-FETALIS;
PROCEDURE-RELATED COMPLICATIONS;
SEVERE RHESUS ISOIMMUNIZATION;
RH D-ALLOIMMUNIZATION;
ANTI-D CONCENTRATIONS;
INTRAVASCULAR TRANSFUSIONS;
GAMMA-GLOBULIN;
EXCHANGE-TRANSFUSION;
D O I:
10.1080/17474086.2017.1305265
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Introduction: Hemolytic disease of the fetus and newborn (HDFN) remains a serious pregnancy complication which can lead to severe fetal anemia, hydrops and perinatal death.Areas covered: This review focusses on the current prenatal management, treatment with intrauterine transfusion (IUT) and promising non-invasive treatment options for HDFN.Expert commentary: IUTs are the cornerstone in prenatal management of HDFN and have significantly improved perinatal outcome in the past decades. IUT is now a relatively safe procedure, however the risk of complications is still high when performed early in the second trimester. Non-invasive management using intravenous immunoglobulin may be a safe alternative and requires further investigation.
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Birchenall, Katherine A.
;
Illanes, Sebastian E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Andes, Foetal Med Unit, Dept Obstet & Gynaecol, Santiago, ChileUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Illanes, Sebastian E.
;
Lopez, Francisco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Andes, Foetal Med Unit, Dept Obstet & Gynaecol, Santiago, ChileUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Lopez, Francisco
;
Overton, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Overton, Timothy
;
Liebling, Rachel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Liebling, Rachel
;
Soothill, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Soothill, Peter W.
;
Abdel-Fattah, Sherif
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Abdel-Fattah, Sherif
;
Denbow, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Bleile, Michelle J.
;
Rijhsinghani, Asha
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Obstet & Gynecol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Rijhsinghani, Asha
;
Dwyre, Denis M.
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Dwyre, Denis M.
;
Raife, Thomas J.
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Birchenall, Katherine A.
;
Illanes, Sebastian E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Andes, Foetal Med Unit, Dept Obstet & Gynaecol, Santiago, ChileUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Illanes, Sebastian E.
;
Lopez, Francisco
论文数: 0引用数: 0
h-index: 0
机构:
Univ Andes, Foetal Med Unit, Dept Obstet & Gynaecol, Santiago, ChileUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Lopez, Francisco
;
Overton, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Overton, Timothy
;
Liebling, Rachel
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Liebling, Rachel
;
Soothill, Peter W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Soothill, Peter W.
;
Abdel-Fattah, Sherif
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
Abdel-Fattah, Sherif
;
Denbow, Mark
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, EnglandUniv Hosp Bristol NHS Fdn Trust, Fetal Med Unit, St Michaels Hosp, Bristol BS2 8EG, Avon, England
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Bleile, Michelle J.
;
Rijhsinghani, Asha
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Obstet & Gynecol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Rijhsinghani, Asha
;
Dwyre, Denis M.
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Dwyre, Denis M.
;
Raife, Thomas J.
论文数: 0引用数: 0
h-index: 0
机构:
Roy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USARoy J & Lucille A Carver Coll Med, Dept Pathol, Iowa City, IA 52242 USA