Anabolic-androgenic steroid abuse and testicular function in men; recent insights

被引:7
作者
de Ronde, Willem [1 ,2 ]
Smit, Diederik L. [2 ]
机构
[1] Spaarne Gasthuis, Dept Internal Med, POB 417, NL-2000 AK Haarlem, Netherlands
[2] Elizabeth Tweesteden Ziekenhuis, Dept Internal Med, Tilburg, Netherlands
关键词
RECOVERY;
D O I
10.1016/j.coph.2022.102318
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The use of illegal androgens by young men is not uncommon. The majority of users take multiple courses of androgens during their lifetime, leading to a high cumulative exposure. An inseparable side effect is suppression of gonadal function. Although this usually recovers, recovery can take a long time and is not without symptoms. This review focusses on recent studies that have greatly increased our knowledge of the disruption and recovery of testicular function during and after androgen abuse. For the guidance and treatment of (potential) users, in-depth knowl-edge of this is indispensable.
引用
收藏
页数:5
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共 16 条
  • [1] Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use
    Baggish, Aaron L.
    Weiner, Rory B.
    Kanayama, Gen
    Hudson, James I.
    Lu, Michael T.
    Hoffmann, Udo
    Pope, Harrison G., Jr.
    [J]. CIRCULATION, 2017, 135 (21) : 1991 - +
  • [2] Bhasin S, 1996, NEW ENGL J MED, V335, P1, DOI 10.1056/nejm199607043350101
  • [3] Recovery of reproductive function following androgen abuse
    Christou, Maria A.
    Tigas, Stelios
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2018, 25 (03) : 195 - 200
  • [4] Anabolic androgenic steroid abuse in young males
    de Ronde, Willem
    Smit, Diederik L.
    [J]. ENDOCRINE CONNECTIONS, 2020, 9 (04): : R102 - R111
  • [5] Commentary: Androgens and "Anabolic Steroids": The One-Headed Janus
    Handelsman, David J.
    [J]. ENDOCRINOLOGY, 2011, 152 (05) : 1752 - 1754
  • [6] Health consequences of androgenic anabolic steroid use
    Horwitz, H.
    Andersen, J. T.
    Dalhoff, K. P.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2019, 285 (03) : 333 - 340
  • [7] Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis
    Liu, PY
    Swerdloff, RS
    Christenson, PD
    Handelsman, DJ
    Wang, C
    [J]. LANCET, 2006, 367 (9520) : 1412 - 1420
  • [8] Serum Insulin-like Factor 3 Levels Are Reduced in Former Androgen Users, Suggesting Impaired Leydig Cell Capacity
    Rasmussen, Jon Jarlov
    Albrethsen, Jakob
    Frandsen, Mikkel Nicklas
    Jorgensen, Niels
    Juul, Anders
    Kistorp, Caroline
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2021, 106 (07) : E2664 - E2672
  • [9] In men, peripheral estradiol levels directly reflect the action of estrogens at the hypothalamo-pituitary level to inhibit gonadotropin secretion
    Raven, Garrett
    de Jong, Frank H.
    Kaufman, Jean-Marc
    de Ronde, Willem
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (09) : 3324 - 3328
  • [10] Shankara-Narayana N., 2020, The Journal of clinical endocrinology and metabolism, V105