Role of Epstein-Barr Virus and Human Papillomavirus Coinfection in Cervical Cancer: Epidemiology, Mechanisms and Perspectives

被引:18
|
作者
Blanco, Rances [1 ]
Carrillo-Beltran, Diego [1 ]
Osorio, Julio C. [2 ]
Calaf, Gloria M. [3 ,4 ]
Aguayo, Francisco [5 ,6 ]
机构
[1] Univ Chile, Inst Ciencias Biomed ICBM, Programa Virol, Fac Med, Santiago 8380000, Chile
[2] Univ Valle, Populat Registry Cali, Dept Pathol, Cali 760042, Colombia
[3] Univ Tarapaca, Inst Alta Invest, Arica 1000000, Chile
[4] Columbia Univ, Ctr Radiol Res, Med Ctr, New York, NY 10032 USA
[5] Univ Tarapaca, Arica 1000000, Chile
[6] Univ Chile, Fac Med, Adv Ctr Chron Dis ACCDiS, Santiago 8330024, Chile
来源
PATHOGENS | 2020年 / 9卷 / 09期
关键词
Epstein-Barr virus; human papillomavirus; coinfection; cervical cancer; tissue-infiltrating lymphocytes; EPITHELIAL-MESENCHYMAL TRANSITION; RISK HUMAN PAPILLOMAVIRUSES; NF-KAPPA-B; NASOPHARYNGEAL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; GASTRIC-CARCINOMA; GENE-EXPRESSION; PHYSICAL STATUS; EBNA1; PROTEIN; SYRIAN WOMEN;
D O I
10.3390/pathogens9090685
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
High-risk human papillomavirus (HR-HPV) is etiologically associated with the development and progression of cervical cancer, although other factors are involved. Epstein-Barr virus (EBV) detection in premalignant and malignant tissues from uterine cervix has been widely reported; however, its contribution to cervical cancer development is still unclear. Here, a comprehensive analysis regarding EBV presence and its potential role in cervical cancer, the frequency of EBV/HR-HPV coinfection in uterine cervix and EBV infection in tissue-infiltrating lymphocytes were revised. Overall, reports suggest a potential link of EBV to the development of cervical carcinomas in two possible pathways: (1) Infecting epithelial cells, thus synergizing with HR-HPV (direct pathway), and/or (2) infecting tissue-infiltrating lymphocytes that could generate local immunosuppression (indirect pathway). In situ hybridization (ISH) and/or immunohistochemical methods are mandatory for discriminating the cell type infected by EBV. However, further studies are needed for a better understanding of the EBV/HR-HPV coinfection role in cervical carcinogenesis.
引用
收藏
页码:1 / 15
页数:17
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