Role of Epstein-Barr Virus and Human Papillomavirus Coinfection in Cervical Cancer: Epidemiology, Mechanisms and Perspectives

被引:23
作者
Blanco, Rances [1 ]
Carrillo-Beltran, Diego [1 ]
Osorio, Julio C. [2 ]
Calaf, Gloria M. [3 ,4 ]
Aguayo, Francisco [5 ,6 ]
机构
[1] Univ Chile, Inst Ciencias Biomed ICBM, Programa Virol, Fac Med, Santiago 8380000, Chile
[2] Univ Valle, Populat Registry Cali, Dept Pathol, Cali 760042, Colombia
[3] Univ Tarapaca, Inst Alta Invest, Arica 1000000, Chile
[4] Columbia Univ, Ctr Radiol Res, Med Ctr, New York, NY 10032 USA
[5] Univ Tarapaca, Arica 1000000, Chile
[6] Univ Chile, Fac Med, Adv Ctr Chron Dis ACCDiS, Santiago 8330024, Chile
关键词
Epstein-Barr virus; human papillomavirus; coinfection; cervical cancer; tissue-infiltrating lymphocytes; EPITHELIAL-MESENCHYMAL TRANSITION; RISK HUMAN PAPILLOMAVIRUSES; NF-KAPPA-B; NASOPHARYNGEAL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; GASTRIC-CARCINOMA; GENE-EXPRESSION; PHYSICAL STATUS; EBNA1; PROTEIN; SYRIAN WOMEN;
D O I
10.3390/pathogens9090685
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
High-risk human papillomavirus (HR-HPV) is etiologically associated with the development and progression of cervical cancer, although other factors are involved. Epstein-Barr virus (EBV) detection in premalignant and malignant tissues from uterine cervix has been widely reported; however, its contribution to cervical cancer development is still unclear. Here, a comprehensive analysis regarding EBV presence and its potential role in cervical cancer, the frequency of EBV/HR-HPV coinfection in uterine cervix and EBV infection in tissue-infiltrating lymphocytes were revised. Overall, reports suggest a potential link of EBV to the development of cervical carcinomas in two possible pathways: (1) Infecting epithelial cells, thus synergizing with HR-HPV (direct pathway), and/or (2) infecting tissue-infiltrating lymphocytes that could generate local immunosuppression (indirect pathway). In situ hybridization (ISH) and/or immunohistochemical methods are mandatory for discriminating the cell type infected by EBV. However, further studies are needed for a better understanding of the EBV/HR-HPV coinfection role in cervical carcinogenesis.
引用
收藏
页码:1 / 15
页数:17
相关论文
共 117 条
[1]   Association of EBV and HPV co-infection with the development of cervical cancer in ethnic Uyghur women [J].
Abudoukadeer, A. ;
Niyazi, M. ;
Aikula, A. ;
Kamilijiang, M. ;
Sulaiman, X. ;
Mutailipu, A. ;
Abudula, A. .
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2015, 36 (05) :546-550
[2]   Co-prevalence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian women with breast cancer [J].
Al Moustafa, Ala-Eddin ;
Al-Antary, Noor ;
Aboulkassim, Tahar ;
Akil, Nizar ;
Batist, Gerald ;
Yasmeen, Amber .
HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2016, 12 (07) :1936-1939
[3]   Co-Incidence of Epstein-Barr Virus and High-Risk Human Papillomaviruses in Cervical Cancer of Syrian Women [J].
Al-Thawadi, Hamda ;
Ghabreau, Lina ;
Aboulkassim, Tahar ;
Yasmeen, Amber ;
Vranic, Semir ;
Batist, Gerald ;
Al Moustafa, Ala-Eddin .
FRONTIERS IN ONCOLOGY, 2018, 8
[4]   Epstein-Barr virus microRNAs reduce immune surveillance by virus-specific CD8+ T cells [J].
Albanese, Manuel ;
Tagawa, Takanobu ;
Bouvet, Mickael ;
Maliqi, Liridona ;
Lutter, Dominik ;
Hoser, Jonathan ;
Hastreiter, Maximilian ;
Hayes, Mitch ;
Sugden, Bill ;
Martin, Larissa ;
Moosmann, Andreas ;
Hammerschmidt, Wolfgang .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (42) :E6467-E6475
[5]  
Ammatuna P, 2000, J MED VIROL, V62, P410, DOI 10.1002/1096-9071(200012)62:4<410::AID-JMV3>3.0.CO
[6]  
2-J
[7]   Understanding the HPV integration and its progression to cervical cancer [J].
Araceli Oyervides-Munoz, Mariel ;
Ali Perez-Maya, Antonio ;
Frecia Rodriguez-Gutierrez, Hazyadee ;
Sofia Gomez-Macias, Gabriela ;
Raul Fajardo-Ramirez, Oscar ;
Trevino, Victor ;
Alberto Barrera-Saldana, Hugo ;
Lourdes Garza-Rodriguez, Maria .
INFECTION GENETICS AND EVOLUTION, 2018, 61 :134-144
[8]   Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis [J].
Arbyn, Marc ;
Weiderpass, Elisabete ;
Bruni, Laia ;
de Sanjose, Silvia ;
Saraiya, Mona ;
Ferlay, Jacques ;
Bray, Freddie .
LANCET GLOBAL HEALTH, 2020, 8 (02) :E191-E203
[9]   High Levels of EBV-Encoded RNA 1 (EBER1) Trigger Interferon and Inflammation-Related Genes in Keratinocytes Expressing HPV16 E6/E7 [J].
Aromseree, Sirinart ;
Middeldorp, Jaap M. ;
Pientong, Chamsai ;
van Eijndhoven, Monique ;
Ramayanti, Octavio ;
Lougheed, Sinead M. ;
Pegtel, D. Michiel ;
Steenbergen, Renske D. M. ;
Ekalaksananan, Tipaya .
PLOS ONE, 2017, 12 (01)
[10]   Possible contributing role of Epstein-Barr virus (EBV) as a cofactor in human papillomavirus (HPV)-associated cervical carcinogenesis [J].
Aromseree, Sirinart ;
Pientong, Chamsai ;
Swangphon, Piyawut ;
Chaiwongkot, Arkom ;
Patarapadungkit, Natcha ;
Kleebkaow, Pilaiwan ;
Tungsiriwattana, Thumwadee ;
Kongyingyoes, Bunkerd ;
Vendrig, Tineke ;
Middeldorp, Jaap M. ;
Ekalaksananan, Tipaya .
JOURNAL OF CLINICAL VIROLOGY, 2015, 73 :70-76