Regional lung blood flow and ventilation in upright humans studied with quantitative SPECT

被引：38

作者：

Petersson, Johan ^{[1
,2
]}

Rohdin, Malin ^{[3
]}

Sanchez-Crespo, Alejandro ^{[4
,5
]}

Nyren, Sven ^{[6
]}

Jacobsson, Hans ^{[4
,6
]}

Larsson, Stig A. ^{[4
,5
]}

Lindahl, Sten G. E. ^{[1
,2
]}

Linnarsson, Dag ^{[3
]}

Neradilek, Blazej ^{[7
]}

Polissar, Nayak L. ^{[7
]}

Glenny, Robb W. ^{[1
,2
,8
,9
,10
]}

Mure, Margareta ^{[1
,2
]}

机构：

[1] Karolinska Univ, Dept Anesthesiol & Intens Care, Hosp Solna, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Anesthesiol & Intens Care Med, S-17177 Stockholm, Sweden

[3] Karolinska Inst, Dept Physiol & Pharmacol, Sect Environm Physiol, S-17177 Stockholm, Sweden

[4] Karolinska Univ, Hosp Solna, Nucl Med Sect, Dept Hosp Phys, S-17176 Stockholm, Sweden

[5] Stockholm Univ, Dept Oncol Pathol, S-17177 Stockholm, Sweden

[6] Karolinska Univ, Hosp Solna, Dept Radiol, S-17176 Stockholm, Sweden

[7] Mt Whisper Light Stat Consulting, Seattle, WA USA

[8] Univ Washington, Dept Med, Seattle, WA 98195 USA

[9] Univ Washington, Dept Physiol, Seattle, WA 98195 USA

[10] Univ Washington, Dept Biophys, Seattle, WA 98195 USA

来源：

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2009年 / 166卷 / 01期

基金：

英国医学研究理事会;

关键词：

SPECT; Lung blood flow; Ventilation; Regional perfusion; Single-photon-emission computed tomography; ANESTHETIZED-PARALYZED MAN; PULMONARY PERFUSION; INSPIRED GAS; SPATIAL-DISTRIBUTION; BODY POSITION; SUPINE MAN; GRAVITY; DENSITY; POSTURE; PRONE;

D O I：

10.1016/j.resp.2009.01.008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We used quantitative Single Photon Emission Computed Tomography (SPECT) to study the effect of the upright posture on regional lung blood flow and ventilation. Nine (upright) plus seven (prone and supine) healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation were marked in sitting upright, supine and prone postures using (113m)In-labeled macroaggregates and inhaled Technegas ((99m)Tc); both remain fixed in the lung after administration. All images were obtained while supine. In comparison with horizontal postures, both blood flow and ventilation were greater in caudal regions when upright. The redistribution was greater for blood flow than for ventilation, resulting in decreasing ventilation-to-perfusion ratios down the lung when upright. We conclude that gravity redistributes regional blood flow and ventilation in the upright posture, while the influence is much less in the supine and prone postures. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：54 / 60

页数：7

共 49 条

[1]

Almquist HM, 1997, J NUCL MED, V38, P962

[2]

AMIS TC, 1984, RESP PHYSIOL, V56, P145, DOI 10.1016/0034-5687(84)90100-2

[3] DISTRIBUTION OF PULMONARY PERFUSION IN ERECT MAN [J].

ANTHONISEN, NR ;

MILICEMI.J .

JOURNAL OF APPLIED PHYSIOLOGY, 1966, 21 (03) :760-+

[4] HEMODYNAMIC CHANGES AT DIFFERENT LUNG VOLUMES [J].

ARBORELIUS, M ;

LILJA, B .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1972, 29 (04) :359-+

[5]

BAKE B, 1967, SCAND J RESPIR DIS, V48, P189

[6] DIFFERENCES IN REGIONAL VASCULAR CONDUCTANCES IN ISOLATED DOG LUNGS [J].

BECK, KC ;

REHDER, K .

JOURNAL OF APPLIED PHYSIOLOGY, 1986, 61 (02) :530-538

[7] REGIONAL LUNG DENSITY AND BLOOD-VOLUME IN NONSMOKING AND SMOKING SUBJECTS MEASURED BY PET [J].

BRUDIN, LH ;

RHODES, CG ;

VALIND, SO ;

WOLLMER, P ;

HUGHES, JMB .

JOURNAL OF APPLIED PHYSIOLOGY, 1987, 63 (04) :1324-1334

[8]

BRYAN AC, 1964, J APPL PHYSL, V19

[9] TECHNEGAS - A NEW VENTILATION AGENT FOR LUNG-SCANNING [J].

BURCH, WM ;

SULLIVAN, PJ ;

MCLAREN, CJ .

NUCLEAR MEDICINE COMMUNICATIONS, 1986, 7 (12) :865-&

[10] CRANIO-CAUDAL DISTRIBUTION OF INSPIRED GAS AND PERFUSION IN SUPINE MAN [J].

ENGEL, LA ;

PREFAUT, C .

RESPIRATION PHYSIOLOGY, 1981, 45 (01) :43-53

← 1 2 3 4 5 →