cis- and trans-decahydro-1,6-naphthyridines.: Stereoselective synthesis and stereochemistry

被引：0
作者：
Esipova, T. V. [1 ]
Borisenko, A. A. [1 ]
Grishina, G. V. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119992, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 42卷 / 06期
关键词：
Organic Chemistry; Cyanide; Hydride; Nucleophilic Addition; Stereoselective Synthesis;
D O I：
10.1134/S1070428006060194
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New 1,6-disubstituted trans-decahydro-1,6-naphthyridines were synthesized by stereoselective nucleophilic addition of hydride and cyanide ions to 1,2,3,4,5,6,7,8-octabydro-1,6-naphthyridines, and their predominant conformations were determined. Some trans-decahydro-1,6-naphthyridine derivatives were found to exhibit anti-HIV activity.
引用
收藏
页码：922 / 928
页数：7
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