cis- and trans-decahydro-1,6-naphthyridines.: Stereoselective synthesis and stereochemistry

被引：0

作者：

Esipova, T. V. ^{[1
]}

Borisenko, A. A. ^{[1
]}

Grishina, G. V. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119992, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 42卷 / 06期

关键词：

Organic Chemistry; Cyanide; Hydride; Nucleophilic Addition; Stereoselective Synthesis;

D O I：

10.1134/S1070428006060194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New 1,6-disubstituted trans-decahydro-1,6-naphthyridines were synthesized by stereoselective nucleophilic addition of hydride and cyanide ions to 1,2,3,4,5,6,7,8-octabydro-1,6-naphthyridines, and their predominant conformations were determined. Some trans-decahydro-1,6-naphthyridine derivatives were found to exhibit anti-HIV activity.

引用

页码：922 / 928

页数：7

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