Familial clustering of classic Kaposi sarcoma

被引：35

作者：

Guttman-Yassky, E

Cohen, A

Kra-Oz, Z

Friedman-Birnbaum, R

Sprecher, E

Zaltzman, N

Friedman, E

Silbermann, M

Rubin, D

Linn, S

Whitby, D

Gideoni, O

Pollack, S

Bergman, R

Sarid, R

机构：

[1] Rambam Med Ctr, Dept Dermatol, Haifa, Israel

[2] Rambam Med Ctr, Dept Virol, Haifa, Israel

[3] Rambam Med Ctr, Dept Immunol, Haifa, Israel

[4] Rambam Med Ctr, Epidemiol Unit, Haifa, Israel

[5] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Dept Cell Biol & Anat, IL-31096 Haifa, Israel

[6] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

[7] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel

[8] NCI, Viral Epidemiol Sect, AIDS Vaccine Program, Frederick, MD 21701 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 189卷 / 11期

关键词：

D O I：

10.1086/386308

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus ( KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case.

引用

页码：2023 / 2026

页数：4

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