Metabolic impact of obesity in childhood

被引：57
作者：
Caprio, S
Tamborlane, WV
机构：
[1] Yale Univ, Sch Med, Dept Pediat, Div Endocrinol, New Haven, CT 06520 USA
[2] Yale Univ, Sch Med, Yale Gen Clin Res Ctr, New Haven, CT 06520 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1999年 / 28卷 / 04期
关键词：
D O I：
10.1016/S0889-8529(05)70099-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Childhood obesity currently is a growing problem in the United States. Using the euglycemic-hyperinsulinemic and hyperglycemic clamp techniques along with magnetic resonance imaging, the authors examined changes in glucose and lipid metabolism in vivo and their relationship to fat distribution in obese children. The studies indicated that increased visceral fat, hyperinsulinemia, and insulin resistance are closely linked abnormalities that are expressed early in the natural history of obesity.
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页码：731 / +
页数：18
相关论文
共 60 条
[1]  
ARNER P, 1988, DIABETES METAB REV, V4, P507
[2]   THE ANTI-LIPOLYTIC EFFECT OF INSULIN IN HUMAN ADIPOSE-TISSUE IN OBESITY, DIABETES-MELLITUS, HYPERINSULINEMIA, AND STARVATION [J].
ARNER, P ;
BOLINDER, J ;
ENGFELDT, P ;
OSTMAN, J .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1981, 30 (08) :753-760
[3]   Plasma leptin in children: Relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure [J].
Arslanian, S ;
Suprasongsin, C ;
Kalhan, SC ;
Drash, AL ;
Brna, R ;
Janosky, JE .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1998, 47 (03) :309-312
[4]   Insulin sensitivity, lipids, and body composition in childhood: Is ''syndrome X'' present? [J].
Arslanian, S ;
Suprasongsin, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) :1058-1062
[5]   Glucose-fatty acid interactions in prepubertal and pubertal children: Effects of lipid infusion [J].
Arslanian, S ;
Suprasongsin, C .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 272 (04) :E523-E529
[6]   The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity [J].
Attia, N ;
Tamborlane, WV ;
Heptulla, R ;
Maggs, D ;
Grozman, A ;
Sherwin, RS ;
Caprio, S .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (05) :1467-1471
[7]   INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS AS GLUCOREGULATORS [J].
BAXTER, RC .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1995, 44 (10) :12-17
[8]   ACUTE ELEVATION OF FREE FATTY-ACID LEVELS LEADS TO HEPATIC INSULIN RESISTANCE IN OBESE SUBJECTS [J].
BEVILACQUA, S ;
BONADONNA, R ;
BUZZIGOLI, G ;
BONI, C ;
CIOCIARO, D ;
MACCARI, F ;
GIORICO, MA ;
FERRANNINI, E .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1987, 36 (05) :502-506
[9]   MECHANISMS OF FATTY ACID-INDUCED INHIBITION OF GLUCOSE-UPTAKE [J].
BODEN, G ;
CHEN, XH ;
RUIZ, J ;
WHITE, JV ;
ROSSETTI, L .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2438-2446
[10]   EFFECTS OF INSULIN ON FATTY-ACID REESTERIFICATION IN HEALTHY-SUBJECTS [J].
BODEN, G ;
CHEN, XH ;
DESANTIS, RA ;
KENDRICK, Z .
DIABETES, 1993, 42 (11) :1588-1593
123456