Proopiomelanocortin and energy balance: Insights from human and murine genetics

被引：167

作者：

Coll, AP

Farooqu, IS

Challis, BG

Yeo, GSH

O'Rahilly, S

机构：

[1] Addenbrookes Hosp, Cambridge Inst Med Res, Univ Dept Med, Cambridge CB2 2QQ, England

[2] Addenbrookes Hosp, Cambridge Inst Med Res, Univ Dept Clin Biochem, Cambridge CB2 2QQ, England

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2004年 / 89卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1210/jc.2004-0428

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Proopiomelanocortin ( POMC) undergoes extensive and tissue-specific posttranslational processing to yield a range of biologically active peptides. Historically, the most clearly defined roles of these peptides are in the control of adrenal steroidogenesis by corticotroph-derived ACTH and skin pigmentation by alphaMSH. However, a rapidly expanding body of work has established that POMC-derived peptides synthesized in neurons of the hypothalamus play a central role in the control of energy homeostasis. We review how inherited abnormalities in POMC synthesis and processing and defects in the action of POMC-derived peptides in both humans and mice have helped shape our current understanding of the importance of the melanocortin system in human energy balance.

引用

收藏

页码：2557 / 2562

页数：6

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