Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway

被引：52
|
作者：
Zhu, Ke-Xue [1 ]
Nie, Shao-Ping [1 ]
Li, Chuan [1 ]
Gong, Deming [1 ,2 ]
Xie, Ming-Yong [1 ]
机构：
[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
[2] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand
来源：
CARBOHYDRATE POLYMERS | 2014年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma atrum polysaccharide; Aorta; Vascular endothelium; Vasorelaxation; HYPERGLYCEMIA; EXPRESSION; APOPTOSIS; ENDOTHELIUM; BCL-2; BAX; PROGRESSION; ACTIVATION; MATTER; BRAIN;
D O I：
10.1016/j.carbpol.2013.12.080
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：520 / 527
页数：8
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