Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway

被引：52
|
作者：
Zhu, Ke-Xue [1 ]
Nie, Shao-Ping [1 ]
Li, Chuan [1 ]
Gong, Deming [1 ,2 ]
Xie, Ming-Yong [1 ]
机构：
[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
[2] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand
来源：
CARBOHYDRATE POLYMERS | 2014年 / 103卷
基金：
中国国家自然科学基金;
关键词：
Ganoderma atrum polysaccharide; Aorta; Vascular endothelium; Vasorelaxation; HYPERGLYCEMIA; EXPRESSION; APOPTOSIS; ENDOTHELIUM; BCL-2; BAX; PROGRESSION; ACTIVATION; MATTER; BRAIN;
D O I：
10.1016/j.carbpol.2013.12.080
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：520 / 527
页数：8
相关论文
共 50 条
  • [31] Involvement of the PI3K/Akt pathway in the hypoglycemic effects of sea cucumber Apostichopus japonicas in diabetic rats
    Wang, Jing-Feng
    Fu, Jia
    Xu, Lei-Lei
    Yang, Yan-Cun
    Wang, Yu-Ming
    Xue, Chang-Hu
    Shenzhen Daxue Xuebao (Ligong Ban)/Journal of Shenzhen University Science and Engineering, 2011, 28 (02): : 172 - 177
  • [32] Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats
    Du, F.
    Wang, L.
    Qian, W.
    Liu, S.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2009, 21 (11): : 1229 - +
  • [33] Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats
    Liu, Kang
    Yang, Yingcong
    Zhou, Fang
    Xiao, Yeda
    Shi, Liwei
    NEUROREPORT, 2020, 31 (09) : 644 - 649
  • [34] Insulin upregulates betatrophin expression via PI3K/Akt pathway
    Lu, Puhan
    Chen, Xi
    Zhang, Zeqing
    Zhang, Jianhua
    Yang, Yan
    Liu, Zhelong
    Xie, Junhui
    Shao, Shiying
    Zhou, Xinrong
    Hu, Shuhong
    He, Wentao
    Zhao, Jiajun
    Yu, Xuefeng
    SCIENTIFIC REPORTS, 2017, 7
  • [35] Isorhamnetin Improves Oocyte Maturation by Activating the Pi3k/Akt Signaling Pathway
    Li, Xiaoya
    Cheng, Jianyong
    Yao, Qichun
    Duan, Jiaxin
    Chen, Huali
    Zhang, Zelin
    Yang, Li
    Hua, Rongmao
    Li, Qingwang
    MOLECULAR NUTRITION & FOOD RESEARCH, 2024, 68 (15)
  • [36] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
    Huemer F.
    Bartsch R.
    Gnant M.
    Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
  • [37] LncRNA HOTAIR improves diabetic cardiomyopathy by increasing viability of cardiomyocytes through activation of the PI3K/Akt pathway
    Qi, Kun
    Zhong, Jianke
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) : 4817 - 4823
  • [38] Insulin upregulates betatrophin expression via PI3K/Akt pathway
    Puhan Lu
    Xi Chen
    Zeqing Zhang
    Jianhua Zhang
    Yan Yang
    Zhelong Liu
    Junhui Xie
    Shiying Shao
    Xinrong Zhou
    Shuhong Hu
    Wentao He
    Jiajun Zhao
    Xuefeng Yu
    Scientific Reports, 7
  • [39] Effect of Tang-Luo-Ning on the PI3K/Akt pathway and the PERK pathway in rats with diabetic peripheral neuropathy
    Guo, Yuxin
    Zhang, Taojing
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2018, 34
  • [40] PI3K/Akt Pathway Mutations in Retinoblastoma
    Cohen, Yoram
    Merhavi-Shoham, Efrat
    Avraham-Lubin, Bat Chen R.
    Savetsky, Michael
    Frenkel, Shahar
    Pe'er, Jacob
    Goldenberg-Cohen, Nitza
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (11) : 5054 - 5056
12345