Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway

被引：53

作者：

Zhu, Ke-Xue ^{[1
]}

Nie, Shao-Ping ^{[1
]}

Li, Chuan ^{[1
]}

Gong, Deming ^{[1
,2
]}

Xie, Ming-Yong ^{[1
]}

机构：

[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China

[2] Univ Auckland, Sch Biol Sci, Auckland 1, New Zealand

来源：

CARBOHYDRATE POLYMERS | 2014年 / 103卷

基金：

中国国家自然科学基金;

关键词：

Ganoderma atrum polysaccharide; Aorta; Vascular endothelium; Vasorelaxation; HYPERGLYCEMIA; EXPRESSION; APOPTOSIS; ENDOTHELIUM; BCL-2; BAX; PROGRESSION; ACTIVATION; MATTER; BRAIN;

D O I：

10.1016/j.carbpol.2013.12.080

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：520 / 527

页数：8

共 50 条

[1] Ailanthone Inhibits Cell Proliferation in Tongue Squamous Cell Carcinoma via PI3K/AKT Pathway
Wang, Shuhan
Cui, Qixiao
Chen, Xiaoyu
Zhu, Xuejie
Lin, Kehao
Zheng, Qiusheng
Wang, Yuliang
Li, Defang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
[2] Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats
Yang, Ying
Fang, Hui
Xu, Gang
Zhen, Yanfeng
Zhang, Yazhong
Tian, Jinli
Zhang, Dandan
Zhang, Guyue
Xu, Jing
MOLECULAR MEDICINE REPORTS, 2018, 18 (02) : 2449 - 2457
[3] Role of the PI3K/AKT signalling pathway in apoptotic cell death in the cerebral cortex of streptozotocin-induced diabetic rats
Meng, Yan
Wang, Weiwei
Kang, Jinsong
Wang, Xinxue
Sun, Liankun
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 13 (05) : 2417 - 2422
[4] Betaine Alleviates Cognitive Deficits in Diabetic Rats via PI3K/Akt Signaling Pathway Regulation
Huang, Bingqing
Hu, Xiaoli
Hu, Jie
Chen, Zhenfei
Zhao, Hao
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2020, 49 (03) : 270 - 278
[5] Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing
Jere, Sandy W.
Houreld, Nicolette N.
Abrahamse, Heidi
CYTOKINE & GROWTH FACTOR REVIEWS, 2019, 50 : 52 - 59
[6] Safflower polysaccharide induces cervical cancer cell apoptosis via inhibition of the PI3K/Akt pathway
Yang, J.
Wang, R.
Feng, Q.
Wang, Y. -X.
Zhang, Y. -Y.
Wu, W. -H.
Ge, P. -L.
Qi, J. -P.
SOUTH AFRICAN JOURNAL OF BOTANY, 2018, 118 : 209 - 215
[7] Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway
Wang, Na
Han, Yaling
Tao, Jie
Huang, Mingfang
You, Yang
Zhang, Huimin
Liu, Shaowei
Zhang, Xiaolin
Yan, Chenghui
ATHEROSCLEROSIS, 2011, 218 (02) : 543 - 551
[8] Effect of Donepezil on Vascular Dementia in Rats via PI3K/AKT Pathway
Zhang, Jianmin
Zhu, Qianwen
Wang, Xingnan
Wang, Jian
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2022, 12 (05) : 1046 - 1052
[9] Quercetin Suppresses HeLa Cells by Blocking PI3K/Akt Pathway
Xiang, Tao
Fang, Yong
Wang, Shi-xuan
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2014, 34 (05) : 740 - 744
[10] LncRNA HOTAIR improves diabetic cardiomyopathy by increasing viability of cardiomyocytes through activation of the PI3K/Akt pathway
Qi, Kun
Zhong, Jianke
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 16 (06) : 4817 - 4823

← 1 2 3 4 5 →