Modulation of the conformational state of mitochondrial complex I as a target for therapeutic intervention

被引：25
作者：
Galkin, Alexander [1 ,2 ]
Moncada, Salvador [3 ]
机构：
[1] Weill Cornell Med Coll, Feil Family Brain & Mind Res Inst, 401 East 61st St,5th floor, New York, NY 10065 USA
[2] Queens Univ Belfast, Sch Biol Sci, Ctr Med Biol, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland
[3] Univ Manchester, Manchester Canc Res Ctr, Wilmslow Rd, Manchester M20 4QL, Lancs, England
来源：
INTERFACE FOCUS | 2017年 / 7卷 / 02期
关键词：
modulation of mitochondrial complex I; therapeutic intervention; ischaemia/reperfusion; nitric oxide; ROS; NADH-UBIQUINONE OXIDOREDUCTASE; CYTOCHROME-C-OXIDASE; ACTIVE INACTIVE TRANSITION; NITRIC-OXIDE; SUPEROXIDE-PRODUCTION; ISCHEMIA-REPERFUSION; S-NITROSATION; ELECTRON-TRANSPORT; RESPIRATORY-CHAIN; OXIDATIVE-PHOSPHORYLATION;
D O I：
10.1098/rsfs.2016.0104
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In recent years, there have been significant advances in our understanding of the functions of mitochondrial complex I other than the generation of energy. These include its role in generation of reactive oxygen species, involvement in the hypoxic tissue response and its possible regulation by nitric oxide (NO) metabolites. In this review, we will focus on the hypoxic conformational change of this mitochondrial enzyme, the so-called active/deactive transition. This conformational change is physiological and relevant to the understanding of certain pathological conditions including, in the cardiovascular system, ischaemia/reperfusion (I/R) damage. We will discuss how complex I can be affected by NO metabolites and will outline some potential mitochondria-targeted therapies in I/R damage.
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页数：8
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