TOX for tired T cells

被引：33

作者：

Bordon, Yvonne

机构：

[1] Nature Reviews Immunology,

来源：

NATURE REVIEWS IMMUNOLOGY | 2019年 / 19卷 / 08期

关键词：

D O I：

10.1038/s41577-019-0193-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Six studies describe a role for TOX in promoting an ‘exhausted’ CD8+ T cell phenotype in settings of chronic antigenic stimulation, such as persistent viral infections and cancer.

引用

页码：476 / 476

页数：1

共 6 条

[1] TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection [J].

Alfei, Francesca ;

Kanev, Kristiyan ;

Hofmann, Maike ;

Wu, Ming ;

Ghoneim, Hazem E. ;

Roelli, Patrick ;

Utzschneider, Daniel T. ;

von Hoesslin, Madlaina ;

Cullen, Jolie G. ;

Fan, Yiping ;

Eisenberg, Vasyl ;

Wohlleber, Dirk ;

Steiger, Katja ;

Merkler, Doron ;

Delorenzi, Mauro ;

Knolle, Percy A. ;

Cohen, Cyrille J. ;

Thimme, Robert ;

Youngblood, Benjamin ;

Zehn, Dietmar .

NATURE, 2019, 571 (7764) :265-+

[2] TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion [J].

Khan, Omar ;

Giles, Josephine R. ;

McDonald, Sierra ;

Manne, Sasikanth ;

Ngiow, Shin Foong ;

Patel, Kunal P. ;

Werner, Michael T. ;

Huang, Alexander C. ;

Alexander, Katherine A. ;

Wu, Jennifer E. ;

Attanasio, John ;

Yan, Patrick ;

George, Sangeeth M. ;

Bengsch, Bertram ;

Staupe, Ryan P. ;

Donahue, Greg ;

Xu, Wei ;

Amaravadi, Ravi K. ;

Xu, Xiaowei ;

Karakousis, Giorgos C. ;

Mitchell, Tara C. ;

Schuchter, Lynn M. ;

Kaye, Jonathan ;

Berger, Shelley L. ;

Wherry, E. John .

NATURE, 2019, 571 (7764) :211-+

[3] TOX is a critical regulator of tumour-specific T cell differentiation [J].

Scott, Andrew C. ;

Dundar, Friederike ;

Zumbo, Paul ;

Chandran, Smita S. ;

Klebanoff, Christopher A. ;

Shakiba, Mojdeh ;

Trivedi, Prerak ;

Menocal, Laura ;

Appleby, Heather ;

Camara, Steven ;

Zamarin, Dmitriy ;

Walther, Tyler ;

Snyder, Alexandra ;

Femia, Matthew R. ;

Comen, Elizabeth A. ;

Wen, Hannah Y. ;

Hellmann, Matthew D. ;

Anandasabapathy, Niroshana ;

Liu, Yong ;

Altorki, Nasser K. ;

Lauer, Peter ;

Levy, Olivier ;

Glickman, Michael S. ;

Kaye, Jonathan ;

Betel, Doron ;

Philip, Mary ;

Schietinger, Andrea .

NATURE, 2019, 571 (7764) :270-+

[4] TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion [J].

Seo, Hyungseok ;

Chen, Joyce ;

Gonzalez-Avalos, Edahi ;

Samaniego-Castruita, Daniela ;

Das, Arundhoti ;

Wang, Yueqiang H. ;

Lopez-Moyado, Isaac F. ;

Georges, Romain O. ;

Zhang, Wade ;

Onodera, Atsushi ;

Wu, Cheng-Jang ;

Lu, Li-Fan ;

Hogan, Patrick G. ;

Bhandoola, Avinash ;

Rao, Anjana .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (25) :12410-12415

[5] TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma [J].

Wang, Xiaochen ;

He, Qifeng ;

Shen, Haiyuan ;

Xia, Anliang ;

Tian, Wenfang ;

Yu, Weiwei ;

Sun, Beicheng .

JOURNAL OF HEPATOLOGY, 2019, 71 (04) :731-741

[6] Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection [J].

Yao, Chen ;

Sun, Hong-Wei ;

Lacey, Neal E. ;

Ji, Yun ;

Moseman, E. Ashley ;

Shih, Han-Yu ;

Heuston, Elisabeth F. ;

Kirby, Martha ;

Anderson, Stacie ;

Cheng, Jun ;

Khan, Omar ;

Handon, Robin ;

Reilley, Julie ;

Fioravanti, Jessica ;

Hu, Jinhui ;

Gossa, Selamawit ;

Wherry, E. John ;

Gattinoni, Luca ;

McGavern, Dorian B. ;

O'Shea, John J. ;

Schwartzberg, Pamela L. ;

Wu, Tuoqi .

NATURE IMMUNOLOGY, 2019, 20 (07) :890-+

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