Human Intestinal Barrier Function in Health and Disease

被引：639

作者：

Konig, Julia ^{[1
]}

Wells, Jerry ^{[2
]}

Cani, Patrice D. ^{[3
]}

Garcia-Rodenas, Clara L. ^{[4
]}

MacDonald, Tom ^{[5
]}

Mercenier, Annick ^{[4
]}

Whyte, Jacqueline ^{[6
]}

Troost, Freddy ^{[7
]}

Brummer, Robert-Jan ^{[1
]}

机构：

[1] Univ Orebro, Sch Med Sci, Fac Hlth & Med, Nutr Gut Brain Interact Res Ctr, Orebro, Sweden

[2] Wageningen Univ, Host Microbe Interact, Anim Sci, Wageningen, Netherlands

[3] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & BIOtechnol, Metab & Nutr Res Grp, Brussels, Belgium

[4] Nestle Res Ctr, Nutr & Hlth Res, Lausanne, Switzerland

[5] Queen Mary Univ London, Inst Cell & Mol Sci, Barts & London Sch Med & Dent, London, England

[6] Int Life Sci Inst, European Branch, Brussels, Belgium

[7] Maastricht Univ, Dept Internal Med, Univ Hosp Maastricht, Div Gastroenterol Hepatol,Med Ctr, Maastricht, Netherlands

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2016年 / 7卷

关键词：

IRRITABLE-BOWEL-SYNDROME; ENTEROPATHOGENIC ESCHERICHIA-COLI; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CORTICOTROPIN-RELEASING-FACTOR; INDUCED PERMEABILITY CHANGES; INDOMETHACIN-INDUCED CHANGES; TIGHT JUNCTION STRUCTURE; MYOSIN LIGHT-CHAIN; CELIAC-DISEASE; GUT MICROBIOTA;

D O I：

10.1038/ctg.2016.54

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed.

引用

页数：13

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