Common Variable Immunodeficiency Diagnosis, Management, and Treatment

被引：66

作者：

Abbott, Jordan K. ^{[1
]}

Gelfand, Erwin W. ^{[1
]}

机构：

[1] Natl Jewish Hlth, Div Allergy & Immunol, Dept Pediat, Denver, CO 80206 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2015年 / 35卷 / 04期

关键词：

Common variable immunodeficiency; CVID; Antibody deficiency; Primary immune deficiency; Immune activation; Autoimmunity; Lymphoproliferation; REGULATORY T-CELLS; ANTIBODY-DEFICIENCY SYNDROME; GRANULOMATOUS-DISEASE; IMMUNE-DEFICIENCY; B-CELLS; INTRAVENOUS IMMUNOGLOBULIN; IMMUNOLOGICAL FEATURES; REPLACEMENT THERAPY; CYTOKINE PRODUCTION; TNFRSF13B VARIANTS;

D O I：

10.1016/j.iac.2015.07.009

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Common variable immunodeficiency (CVID) refers to a grouping of antibody deficiencies that lack a more specific genetic or phenotypic classification. It is the immunodeficiency classification with the greatest number of constituents, likely because of the numerous ways in which antibody production can be impaired and the frequency in which antibody production becomes impaired in human beings. CVID comprises a heterogeneous group of rare diseases. Consequently, CVID presents a significant challenge for researchers and clinicians. Despite these difficulties, both our understanding of and ability to manage this grouping of complex immune diseases has advanced significantly over the past 60 years.

引用

页码：637 / +

页数：23

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