Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study

被引：21

作者：

Higashi, Tomomi ^{[1
]}

Kambayashi, Yasuhiro ^{[2
]}

Ohkura, Noriyuki ^{[3
]}

Fujimura, Masaki ^{[3
,9
]}

Nakai, Satoshi ^{[4
]}

Honda, Yasushi ^{[5
]}

Saijoh, Kiyofumi ^{[1
]}

Hayakawa, Kazuichi ^{[6
]}

Kobayashi, Fumihisa ^{[7
]}

Michigami, Yoshimasa ^{[8
]}

Olando, Anyenda Enoch ^{[2
]}

Hitomi, Yoshiaki ^{[2
]}

Nakamura, Hiroyuki ^{[2
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Hyg, Kanazawa, Ishikawa 9208640, Japan

[2] Kanazawa Univ, Grad Sch Med Sci, Dept Environm & Prevent Med, Kanazawa, Ishikawa 9208640, Japan

[3] Kanazawa Univ, Grad Sch Med Sci, Dept Resp Med, Kanazawa, Ishikawa 9208640, Japan

[4] Yokohama Natl Univ, Grad Sch Environm & Informat Sci, Yokohama, Kanagawa, Japan

[5] Univ Tsukuba, Fac Hlth & Sport Sci, Tsukuba, Ibaraki 305, Japan

[6] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Kanazawa, Ishikawa 9208640, Japan

[7] Kanazawa Univ, Coll Sci & Engn, Kanazawa, Ishikawa 9208640, Japan

[8] Kanazawa Univ, Environm Preservat Ctr, Kanazawa, Ishikawa 9208640, Japan

[9] Nanao Hosp, Natl Hosp Org, Nanao, Japan

来源：

ATMOSPHERIC ENVIRONMENT | 2014年 / 92卷

关键词：

Asian dust; Kosa; Chronic cough; Daily cough symptom; PM2.5; CAUSE-SPECIFIC MORTALITY; PARTICULATE MATTER; AIR-POLLUTION; SAHARAN DUST; SURFACE OBSERVATIONS; HOSPITAL ADMISSIONS; LIDAR NETWORK; SAND DUST; ASTHMA; TRANSPORT;

D O I：

10.1016/j.atmosenv.2014.04.034

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Asian dust, known as kosa in Japanese, is a major public health concern. In this panel study, we evaluated the effects of exposure to kosa on daily cough occurrence. The study subjects were 86 patients being treated for asthma, cough variant asthma, or atopic cough in Kanazawa University Hospital from January 2011 to June 2011. Daily mean concentrations of kosa and spherical particles were obtained from light detection and ranging (LIDAR) measurements, and were categorized from Grade 1 (0 mu g/m(3)) to 5 (over 100 mu g/m(3)). The association between kosa and cough was analyzed by logistic regression with a generalized estimating equation. Kosa effects on cough were seen for all Grades with potential time lag effect. Particularly at Lag 0 (the day of exposure), a dose response relationship was observed: the odds ratios for Grades 2, 3, 4, and 5 above the referent (Grade 1) were 1.111 (95% confidence interval (CI): 0.995-1.239), 1.171 (95% CI: 1.006 -1.363), 1.357 (95% CI: 1.029-1.788), and 1.414 (95% CI: 0.983-2.036), respectively. Among the patients without asthma, the association was higher: the odds ratios for Grades 2, 3, 4 and 5 were 1.223 (95% CI: 0.999-1.497), 1309 (95% CI: 0.987-1.737), 1.738 (95% CI: 1.029-2.935) and 2.403 (95% CI: 1.158-4.985), respectively. These associations remained after adjusting for the concentration of spherical particles or particulate matter with an aerodynamic diameter of less than 2.5 mu m (PM2.5). Our findings demonstrate that kosa is an environmental factor which induces cough in a dose response relationship. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：506 / 513

页数：8

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