Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest

被引：204
作者：
Fujimori, F
Takahashi, K
Uchida, C
Uchida, T
机构：
[1] Waseda Univ, Adv Res Inst Sci & Engn, GeneSurf, Shinjuku Ku, Tokyo 1698555, Japan
[2] Showa Univ, Sch Pharmaceut Sci, Dept Physiol Chem, Tokyo 142, Japan
[3] Ibaraki Univ, Ctr Hlth, Mito, Ibaraki, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 265卷 / 03期
关键词：
Pin1; KO mouse; Ess1; PPIase; cell cycle;
D O I：
10.1006/bbrc.1999.1736
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells. To investigate the function of Pin1 in mammalian cells, we created mice lacking Pin1. These mice underwent normal development. Although the embryonic Pin1-/- fibroblasts grew normally, they proved significantly deficient in their ability to restart proliferation in response to serum stimulation after G(0) arrest. These results suggest that Pin1 is required for cell cycle progression from G(0) arrest as well as mitosis progression in normal mammalian cells. (C) 1999 Academic Press.
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收藏
页码：658 / 663
页数：6
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