Acute toxicity of industrial endocrine-disrupting chemicals, natural and synthetic sex hormones to the freshwater planarian, Dugesia japonica

被引:17
作者
Li, Mei-Hui [1 ]
机构
[1] Natl Taiwan Univ, Dept Geog, Environm Toxicol Lab, Taipei 10764, Taiwan
关键词
Dugesia japonica; aquatic toxicity; estrogen; androgen; PERSONAL CARE PRODUCTS; WASTE-WATER; DAPHNIA-MAGNA; BISPHENOL-A; MODEL SYSTEM; US STREAMS; IN-VIVO; PHARMACEUTICALS; BENZOTRIAZOLES; SURVIVAL;
D O I
10.1080/02772248.2013.840376
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Many chemicals commonly occurring in surface water are found to be hormonally active. Fourteen compounds including four sex hormones, three synthetic hormones, one non-steroidal anti-androgen, and six industrial endocrine-disrupting chemicals were selected to examine their acute toxicities on the freshwater planarian, Dugesia japonica. Among all test chemicals, diethylstilbestrol had the highest toxicity. Relatively, the toxicities of the synthetic hormones were higher than the natural ones. Among the six industrial endocrine-disrupting chemicals tested, bisphenol A was the most toxic, with a 48-h LC50 of 8.3mg L-1. Overall, the natural or synthetic hormones, other than estrone and estriol, were more acutely toxic to planarians than the industrial endocrine disruptors tested. The acute toxicities of the test chemicals to Dugesia japonica were in the same order of magnitude as those to Daphnia magna based on available published data. Despite this study used non-environmentally relevant levels, such kinds of chemicals do not exist singly in the aquatic environment, but typically act in synergistic and/or additive ways in the complex environmental mixtures, and the total estrogen equivalents are much higher than a single chemical. This study stands as a starting point for other acute and chronic assays, namely using mixtures.
引用
收藏
页码:984 / 991
页数:8
相关论文
共 44 条
[1]   Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna [J].
Barbosa, Isabel R. ;
Nogueira, Antonio J. A. ;
Soares, Amadeu M. V. M. .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2008, 71 (03) :757-764
[2]   Monitoring of natural and synthetic hormones in a polluted river [J].
Barel-Cohen, K ;
Shore, LS ;
Shemesh, M ;
Wenzel, A ;
Mueller, J ;
Kronfeld-Schor, N .
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2006, 78 (01) :16-23
[3]   Pharmaceuticals and Endocrine Disrupting Compounds in US Drinking Water [J].
Benotti, Mark J. ;
Trenholm, Rebecca A. ;
Vanderford, Brett J. ;
Holady, Janie C. ;
Stanford, Benjamin D. ;
Snyder, Shane A. .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2009, 43 (03) :597-603
[4]  
BEST JB, 1982, TERATOGEN CARCIN MUT, V2, P277, DOI 10.1002/1520-6866(1990)2:3/4<277::AID-TCM1770020309>3.0.CO
[5]  
2-8
[6]   Multi-generational effects of four selected environmental oestrogens on Daphnia magna [J].
Brennan, Sarah J. ;
Brougham, Concepta A. ;
Roche, James J. ;
Fogarty, Andrew M. .
CHEMOSPHERE, 2006, 64 (01) :49-55
[7]   Pharmaceuticals, Personal Care Products and Endocrine Disrupting Agents in the Environment - A Review [J].
Caliman, Florentina Anca ;
Gavrilescu, Maria .
CLEAN-SOIL AIR WATER, 2009, 37 (4-5) :277-303
[8]   Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: A review [J].
Campbell, Chris G. ;
Borglin, Sharon E. ;
Green, F. Bailey ;
Grayson, Allen ;
Wozei, Eleanor ;
Stringfellow, William T. .
CHEMOSPHERE, 2006, 65 (08) :1265-1280
[9]   Trace-level analysis of organic contaminants in drinking waters and groundwaters [J].
Capdeville, M. J. ;
Budzinski, H. .
TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2011, 30 (04) :586-606
[10]   Acute toxicity, mutagenicity, and estrogenicity of bisphenol-A and other bisphenols [J].
Chen, MY ;
Ike, M ;
Fujita, M .
ENVIRONMENTAL TOXICOLOGY, 2002, 17 (01) :80-86