Development of highly water-dispersible complexes between coenzyme Q10 and protein hydrolysates

被引：13

作者：

Inada, Asuka ^{[1
]}

Oue, Taishi ^{[2
]}

Yamashita, Soshi ^{[2
]}

Yamasaki, Masao ^{[3
]}

Oshima, Tatsuya ^{[2
]}

Matsuyama, Hideto ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Engn, Dept Chem Sci & Engn, Ctr Membrane & Film Technol,Nada Ku, 1-1 Rokkodai Cho, Kobe, Hyogo 6578501, Japan

[2] Univ Miyazaki, Fac Engn, Dept Appl Chem, Nishi Ku, 1-1 Gakuen Kibanadai, Miyazaki 8892192, Japan

[3] Univ Miyazaki, Fac Agr, Dept Biochem & Appl Biosci, Nishi Ku, 1-1 Gakuen Kibanadai, Miyazaki 8892192, Japan

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2019年 / 136卷

基金：

日本学术振兴会;

关键词：

Coenzyme Q(10); Peptide; Complexation; Dispersant; Hydrocolloid; AMINO-ACID-COMPOSITION; BOVINE BETA-CASEIN; DELIVERY-SYSTEMS; FORMULATION DEVELOPMENT; DRUG; SOLUBILITY; ENHANCEMENT; CYCLODEXTRIN; HEMOGLOBIN; CURCUMIN;

D O I：

10.1016/j.ejps.2019.05.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The water-solubility of coenzyme Q(10) (CoQ(10)) is extremely low because of its hydrophobicity, which results in low bioavailability. In this study, peptide mixtures derived from different proteins (casein, albumin, gelatin, lysozyme, zein and hemoglobin) were prepared and used as dispersants of CoQ(10). Most peptide mixtures, except for that derived from lysozyme, enhanced the water-dispersibility of CoQ(10) by forming complexes with CoQ(10). In particular, the apparent solubility of CoQ(10)complexed with the casein hydrolysate (Pep(cas)) was the highest. Pepcas was fractionated by ammonium sulfate precipitation and ultrafiltration to find the most effective peptides for enhancing water-dispersibility of CoQ(10). The peptide fraction that had a relatively hydrophobic nature and peptides of higher-than-average molecular weights (Pep(cas)A) was found to be the most effective. Results from differential thermal analysis and powder X-ray diffraction revealed that the complex between CoQ(10) and Pep(cas)A in the solid state was amorphous. In solution, the complex is a hydrocolloid with particle sizes of 154-279 nm.

引用

页数：7

共 54 条

[1] Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment [J].