Translation Elongation and Recoding in Eukaryotes

被引：152

作者：

Dever, Thomas E. ^{[1
]}

Dinman, Jonathan D. ^{[2
]}

Green, Rachel ^{[3
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD 20892 USA

[2] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

[3] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 08期

关键词：

RIBOSOMAL FRAMESHIFT SIGNALS; MESSENGER-RNA TRANSLATION; SITE TRANSFER-RNA; IMMUNODEFICIENCY-VIRUS TYPE-1; ALLOSTERIC 3-SITE MODEL; PEPTIDYL-TRANSFER-RNA; STEM-LOOP RNA; SACCHAROMYCES-CEREVISIAE; PROTEIN-SYNTHESIS; EF-P;

D O I：

10.1101/cshperspect.a032649

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

n this review, we highlight the current understanding of translation elongation and recoding in eukaryotes. In addition to providing an overview of the process, recent advances in our understanding of the role of the factor elF5A in both translation elongation and termination are discussed. We also highlight mechanisms of translation recoding with a focus on ribosomal frameshifting during elongation. We see that the balance between the basic steps in elongation and the less common recoding events is determined by the kinetics of the different processes as well as by specific sequence determinants.

引用

页数：19

共 191 条

[1] Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome [J].

Abeyrathne, Priyanka D. ;

Koh, Cha San ;

Grant, Timothy ;

Grigorieff, Nikolaus ;

Korostelev, Andrei A. .

ELIFE, 2016, 5

[2] Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expression [J].

Advani, Vivek M. ;

Dinman, Jonathan D. .

BIOESSAYS, 2016, 38 (01) :21-26

[3] Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway [J].

Advani, Vivek M. ;

Belew, Ashton T. ;

Dinman, Jonathan D. .

TRANSLATION, 2013, 1 (01)

[4] Reassigning stop codons via translation termination: How a few eukaryotes broke the dogma [J].

Alkalaeva, Elena ;

Mikhailova, Tatiana .

BIOESSAYS, 2017, 39 (03)

[5] Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3 [J].

Anand, M ;

Chakraburtty, K ;

Marton, MJ ;

Hinnebusch, AG ;

Kinzy, TG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (09) :6985-6991

[6] Structure of eEF3 and the mechanism of transfer RNA release from the E-site [J].

Andersen, Christian B. F. ;

Becker, Thomas ;

Blau, Michael ;

Anand, Monika ;

Halic, Mario ;

Balar, Bharvi ;

Mielke, Thorsten ;

Boesen, Thomas ;

Pedersen, Jan Skov ;

Spahn, Christian M. T. ;

Kinzy, Terri Goss ;

Andersen, Gregers R. ;

Beckmann, Roland .

NATURE, 2006, 443 (7112) :663-668

[7] Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Bα complex [J].

Andersen, GR ;

Valente, L ;

Pedersen, L ;

Kinzy, TG ;

Nyborg, J .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (06) :531-534

[8] Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae [J].

Asakura, T ;

Sasaki, T ;

Nagano, F ;

Satoh, A ;

Obaishi, H ;

Nishioka, H ;

Imamura, H ;

Hotta, K ;

Tanaka, K ;

Nakanishi, H ;

Takai, Y .

ONCOGENE, 1998, 16 (01) :121-130

[9] Inhibition of in vitro and ex vivo translation by a transplatin-modified oligo(2′-O-methylribonucleotide) directed against the HIV-1 gag-pol frameshift signal [J].

Aupeix-Scheidler, K ;

Chabas, S ;

Bidou, L ;

Rousset, JP ;

Leng, M ;

Toulmé, JJ .

NUCLEIC ACIDS RESEARCH, 2000, 28 (02) :438-445

[10] P-site tRNA is a crucial initiator of ribosomal frameshifting [J].

Baranov, PV ;

Gesteland, RF ;

Atkins, JF .

RNA, 2004, 10 (02) :221-230

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