Hyperuricemia and incident atrial fibrillation in a normotensive elderly population in Taiwan

被引：34
作者：
Chuang, S. -Y. [1 ]
Wu, C. -C. [2 ,3 ]
Hsu, P. -F. [3 ,6 ,7 ]
Chen, R. Chia-Yu [1 ]
Liu, W. -L. [1 ]
Hsu, Y. -Y. [1 ]
Pan, W. -H. [1 ,4 ,5 ,8 ,9 ]
机构：
[1] Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan Town 35053, Maioli County, Taiwan
[2] Natl Taiwan Univ Hosp, Branch Hsinchu, Dept Med, Taipei, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[4] Natl Taiwan Univ, Inst Epidemiol, Taipei 10764, Taiwan
[5] Natl Taiwan Univ, Inst Microbiol & Biochem, Taipei 10764, Taiwan
[6] Taipei Vet Gen Hosp, Healthcare & Management Ctr, Taipei, Taiwan
[7] Natl Yang Ming Univ, Dept Med, Taipei, Taiwan
[8] Natl Yang Ming Univ, Dept Med, Sch Publ Hlth, Taipei 112, Taiwan
[9] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
来源：
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2014年 / 24卷 / 09期
关键词：
Atrial fibrillation; Hyperuricemia; Elderly population; SERUM URIC-ACID; HEART-FAILURE; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; UNITED-STATES; ASSOCIATION; PREVALENCE; HEALTH; ROTTERDAM; NUTRITION;
D O I：
10.1016/j.numecd.2014.03.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and aim: Atrial fibrillation (AF) is an important cardiovascular disease in the elderly. The association between hyperuricemia and AF is unclear. Therefore, we aimed to investigate the prospective relationship between uric acid and development of AF in a nationally representative cohort of elderly people. Methods and results: A total of 1485 elderly people (age >= 65 yrs) from the Elderly Nutrition and Health Survey in Taiwan (1999-2000) were without AF on "electrocardiography" at baseline. Incident AF events (International Classification of Diseases, Ninth Revision, Clinical Modification, ICD-9-CM: 427.31) were identified using data from the National Health Insurance Dataset. Hyperuricemia was defined as levels of uric acid > 7.0 mg/dL in men and 6.0 mg/dL in women. A Cox proportional hazards model was used to evaluate the association between hyperuricemia and incident AF. The follow-up period was from 1999 to 2000 to 2008. During the follow-up period (median: 9.16 yrs), 90 AF events occurred (44 in men and 46 in women). Older age, elevated systolic blood pressure, being an ex-smoker, and high uric acid were positively associated with incident AF. Hyperuricemia was positively associated with incident AF in normotensive (age-adjusted hazard ratio (HR): 2.65 and 95% confidence intervals: 1.05-6.69), but not in (1.20: 0.74-1.94) hypertensive individuals (systolic blood pressure >= 130 or diastolic blood pressure >= 85 or using hypertensive medicine). A significant association between hyperuricemia and AF (3.78; 1.24-11.59) remained after adjusting for other potential confounders among normotensive older persons. Conclusion: Hyperuricemia is associated with the development of AF in elderly people with normal blood pressure. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：1020 / 1026
页数：7
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