Why Does Enzyme Not Leach from Metal-Organic Frameworks (MOFs)? Unveiling the Interactions between an Enzyme Molecule and a MOF

被引：139

作者：

Chen, Yao ^{[1
]}

Han, Sungyub ^{[1
]}

Li, Xiao ^{[1
]}

Zhang, Zhenjie ^{[1
]}

Ma, Shengqian ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

INORGANIC CHEMISTRY | 2014年 / 53卷 / 19期

基金：

美国国家科学基金会;

关键词：

RAMAN-SPECTROSCOPY; IMMOBILIZATION; PROTEINS; BIOCATALYSIS; SPECTRA; SURFACE; CAGES;

D O I：

10.1021/ic501062r

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The strong interactions between microperoxidase (MP-11) and Tb-mesoMOF were identified via Raman spectroscopic studies, which revealed that MP-11 molecules interact with the framework of Tb-mesoMOF through pi center dot center dot center dot pi interactions between the heme of MP-11 and the conjugated triazine and benzene rings in the organic ligand of Tb-mesoMOF. The strong interactions facilitate the retention of MP-11 molecules within the metal-organic framework (MOP) pores, which is in striking contrast with the severe leaching of MP-11 from MCM-41 due to the lack of specific interactions between enzyme molecules and the mesoporous silica material.

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收藏

页码：10006 / 10008

页数：3

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