Laser ablation as focal therapy for prostate cancer

被引：47

作者：

Wenger, Hannah ^{[1
]}

Yousuf, Ambereen ^{[2
]}

Oto, Aytekin ^{[2
]}

Eggener, Scott ^{[3
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

[3] Univ Chicago, Urol Sect, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN UROLOGY | 2014年 / 24卷 / 03期

关键词：

focal therapy; laser ablation; prostate cancer;

D O I：

10.1097/MOU.0000000000000044

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewFocal laser ablation (FLA) is an emerging treatment paradigm for prostate cancer that aims to successfully eradicate disease while also reducing the risk of side-effects compared with whole-gland therapies.Recent findingsPreclinical and phase I clinical trials for low-risk prostate cancer have shown that FLA produces accurate, predictable, and reproducible ablation zones with negligible injury to the surrounding tissues. Because FLA is magnetic resonance compatible, the procedure can be monitored with real-time feedback to optimize targeted treatment of cancerous foci and minimize quality-of-life side-effects. The oncologic efficacy of MRI-guided FLA is currently being evaluated in ongoing phase II clinical trials.SummaryFLA is a well tolerated and feasible therapy for low-risk prostate cancer, and the oncologic efficacy of this treatment modality is currently under investigation in phase II clinical trials at several institutions.

引用

页码：236 / 240

页数：5

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