Regulation of Interferon-Dependent mRNA Translation of Target Genes

被引：26

作者：

Kroczynska, Barbara ^{[1
]}

Mehrotra, Swarna ^{[1
]}

Arslan, Ahmet Dirim ^{[1
]}

Kaur, Surinder ^{[1
]}

Platanias, Leonidas C. ^{[1
,2
]}

机构：

[1] Northwestern Univ, Sch Med, Robert H Lurie Comprehens Canc Ctr, Div Hematol Oncol, Chicago, IL USA

[2] Jesse Brown VA Med Ctr, Dept Med, Chicago, IL USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2014年 / 34卷 / 04期

关键词：

ACTIVATED PROTEIN-KINASE; INITIATION-FACTOR; 4B; P70; S6; KINASE; PHOSPHATIDYLINOSITOL; 3-KINASE; SIGNALING PATHWAYS; MAMMALIAN TARGET; TRANSCRIPTIONAL ACTIVATION; ANTIVIRAL ACTIVITY; STIMULATED GENES; I INTERFERONS;

D O I：

10.1089/jir.2013.0148

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.

引用

页码：289 / 296

页数：8

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