Indoles from Simple Anilines and Alkynes: Palladium-Catalyzed C-H Activation Using Dioxygen as the Oxidant

被引：372
作者：
Shi, Zhuangzhi [1 ]
Zhang, Chun [1 ]
Li, Si [1 ]
Pan, Delin [1 ]
Ding, Shengtao [1 ]
Cui, Yuxin [1 ]
Jiao, Ning [1 ,2 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 25期
基金：
美国国家科学基金会;
关键词：
alkynes; C-H activation; indoles; oxidation; palladium; INTRAMOLECULAR AMINOPALLADATION; AEROBIC OXIDATION; INTERNAL ALKYNES; BOND ACTIVATION; ORGANIC-CHEMICALS; DIRECT ARYLATION; ARYL; FUNCTIONALIZATION; CYCLIZATION; ANNULATION;
D O I：
10.1002/anie.200901484
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pd doles it out: A palladium-catalyzed approach to indoles using the title reaction was achieved (see scheme). The oxidant used in this catalytic cycle was O2. Both N-nonsubstituted and N-alkyl monosubstituted anilines can be successfully transformed into the corresponding indoles by this method. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：4572 / 4576
页数：5
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