Neuroendocrine neoplasms of the larynx: Advances in identification, understanding, and management

被引:75
作者
Ferlito, Alfio
Devaney, Kenneth O.
Rinaldo, Alessandra
机构
[1] Univ Udine, Policlin Univ, ENT Clin, Dept Surg Sci, I-33100 Udine, Italy
[2] Foote Hosp, Dept Pathol, Jackson, MI USA
关键词
neuroendocrine neoplasms; larynx; carcinoid tumour; atypical carcinoid tumour; small cell neuroendocrine; carcinoma; paraganglioma;
D O I
10.1016/j.oraloncology.2006.01.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
While 85-90% of laryngeal malignancies prove to be squamous carcinomas, the second most common tumour type found in the laryngeal region will prove to be a member of the family of neuroendocrine tumours. Laryngeal carcinoid tumours have a capacity for metastasis, and so are more aggressive tumours than their light microscopic features might imply - 5-year survival rates are in the vicinity of 50%. Laryngeal atypical carcinoid tumours are lesions with a well-recognized capacity for local recurrence as well as metastasis, with a 5-year survival of just under 50%. Laryngeal small cell neuroendocrine carcinomas are particularly aggressive tumours, with a 5-year survival of no more than 5-10%. Laryngeal paragangliomas are lesions without any real capacity for metastasizing. Surgical excision is the mainstay of treatment of carcinoid tumours, atypical carcinoid tumours, and paragangliomas. Small cell neuroendocrine carcinomas are chiefly treated by way of radiation and chemotherapy; the role of adjuvant therapy in the treatment of atypical carcinoid tumours remains to be established. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:770 / 788
页数:19
相关论文
共 300 条
[1]  
Adlington P, 1972, J Laryngol Otol, V86, P1219, DOI 10.1017/S0022215100076441
[2]   PRIMARY OAT-CELL CARCINOMA OF THE LARYNX [J].
AGUILAR, EA ;
ROBBINS, KT ;
STEPHENS, J ;
DIMERY, IW ;
BATSAKIS, JG .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1987, 10 (01) :26-32
[3]  
Alegre J, 1991, An Otorrinolaringol Ibero Am, V18, P439
[4]   PAIN-INDUCING LARYNGEAL PARAGANGLIOMAS (NON-CHROMAFFIN) [J].
ALI, S ;
AIRD, DW ;
BIHARI, J .
JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1983, 97 (02) :181-188
[5]   Unusual features of metastatic atypical carcinoid of the larynx [J].
Alujevic, A ;
Juric, G ;
Separovic, R ;
Kruslin, B .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1998, 255 (06) :318-321
[6]  
ANDREWS A H Jr, 1955, Ann Otol Rhinol Laryngol, V64, P1034
[7]   MALIGNANT (ATYPICAL) CARCINOID OF THE LARYNX OCCURRING IN A PATIENT WITH LARYNGOTRACHEAL PAPILLOMATOSIS [J].
ANDREWS, TM ;
MYER, CM .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 1992, 13 (04) :238-242
[8]  
ANI AN, 1979, INT SURG, V64, P43
[9]  
[Anonymous], 1979, TUMORS HEAD NECK CLI
[10]   CHIEF CELL HYPERPLASIA IN HUMAN CAROTID-BODY AT HIGH-ALTITUDES - PHYSIOLOGIC AND PATHOLOGIC SIGNIFICANCE [J].
ARIASSTELLA, J ;
VALCARCEL, J .
HUMAN PATHOLOGY, 1976, 7 (04) :361-373