The sarcomeric cytoskeleton: from molecules to motion

被引：157

作者：

Gautel, Mathias ^{[1
,2
]}

Djinovic-Carugo, Kristina ^{[3
,4
]}

机构：

[1] Kings Coll London, BHF Ctr Res Excellence, Randall Div Cell & Mol Biophys, New Hunts House, London SE1 1UL, England

[2] Div Cardiovasc, New Hunts House, London SE1 1UL, England

[3] Univ Vienna, Max F Perutz Labs, Dept Struct & Computat Biol, Campus Vienna Bioctr 5, A-1030 Vienna, Austria

[4] Univ Ljubljana, Fac Chem & Chem Technol, Dept Biochem, Ljubljana 1000, Slovenia

来源：

JOURNAL OF EXPERIMENTAL BIOLOGY | 2016年 / 219卷 / 02期

基金：

奥地利科学基金会;

关键词：

Striated muscle; Sarcomere; Cytoskeleton; Titin; Obscurin; alpha-Actinin; Myomesin; Z-disk; M-band; THIN FILAMENT ARCHITECTURE; DEVELOPING CHICKEN HEART; BAND PROTEINS MYOMESIN; ACTIN CAPPING PROTEIN; X-RAY-DIFFRACTION; SKELETAL-MUSCLE; ALPHA-ACTININ; Z-DISK; MUSCULAR-DYSTROPHY; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE;

D O I：

10.1242/jeb.124941

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by combining architectural, mechanical and signalling functions. This review discusses recent cell biological, biophysical and structural insight into the regulated assembly of sarcomeric cytoskeleton proteins and their roles in dissipating mechanical forces in order to maintain sarcomere integrity during passive extension and active contraction. alpha-Actinin crosslinks in the Z-disk show a pivot-and-rod structure that anchors both titin and actin filaments. In contrast, the myosin crosslinks formed by myomesin in the M-band are of a balland-spring type and may be crucial in providing stable yet elastic connections during active contractions, especially eccentric exercise.

引用

页码：135 / 145

页数：11

共 142 条

[1] The M-band: an elastic web that crosslinks thick filaments in the center of the sarcomere [J].

Agarkova, I ;

Perriard, JC .

TRENDS IN CELL BIOLOGY, 2005, 15 (09) :477-485

[2] The molecular composition of the sarcomeric M-band correlates with muscle fiber type [J].

Agarkova, I ;

Schoenauer, R ;

Ehler, E ;

Carlsson, L ;

Carlsson, E ;

Thornell, LE ;

Perriard, JC .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2004, 83 (05) :193-204

[3] A novel marker for vertebrate embryonic heart, the EH-myomesin isoform [J].

Agarkova, I ;

Auerbach, D ;

Ehler, E ;

Perriard, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (14) :10256-10264

[4] M-band: a safeguard for sarcomere stability? [J].

Agarkova, I ;

Ehler, E ;

Lange, S ;

Schoenauer, R ;

Perriard, JC .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2003, 24 (2-3) :191-203

[5] Transverse stiffness of myofibrils of skeletal and cardiac muscles studied by atomic force microscopy [J].

Akiyama, Nao ;

Ohnuki, Yoshiki ;

Kunioka, Yuki ;

Saeki, Yasutake ;

Yamada, Takenori .

JOURNAL OF PHYSIOLOGICAL SCIENCES, 2006, 56 (02) :145-151

[6] Ca2+-independent binding of an EF-hand domain to a novel motif in the α-actinin-titin complex [J].

Atkinson, RA ;

Joseph, C ;

Kelly, G ;

Muskett, FW ;

Frenkiel, TA ;

Nietlispach, D ;

Pastore, A .

NATURE STRUCTURAL BIOLOGY, 2001, 8 (10) :853-857

[7] Binding of α-actinin to titin:: Implications for Z-disk assembly [J].

Atkinson, RA ;

Joseph, C ;

Dal Piaz, F ;

Birolo, L ;

Stier, G ;

Pucci, P ;

Pastore, A .

BIOCHEMISTRY, 2000, 39 (18) :5255-5264

[8] Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles [J].

Bagnato, P ;

Barone, V ;

Giacomello, E ;

Rossi, D ;

Sorrentino, V .

JOURNAL OF CELL BIOLOGY, 2003, 160 (02) :245-253

[9] Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response [J].

Banerjee, Indroneal ;

Zhang, Jianlin ;

Moore-Morris, Thomas ;

Pfeiffer, Emily ;

Buchholz, Kyle S. ;

Liu, Ao ;

Ouyang, Kunfu ;

Stroud, Matthew J. ;

Gerace, Larry ;

Evans, Sylvia M. ;

McCulloch, Andrew ;

Chen, Ju .

PLOS GENETICS, 2014, 10 (02)

[10] Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G [J].

Barresi, Rita ;

Morris, Charlotte ;

Hudson, Judith ;

Curtis, Elizabeth ;

Pickthall, Clare ;

Bushby, Kate ;

Davies, Nicholas P. ;

Straub, Volker .

NEUROMUSCULAR DISORDERS, 2015, 25 (04) :349-352

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