The Neuroimmunology of Chronic Pain: From Rodents to Humans

被引：83
作者：
Grace, Peter M. [1 ]
Tawfik, Vivianne L. [2 ]
Svensson, Camilla, I [3 ]
Burton, Michael D. [4 ]
Loggia, Marco L. [5 ]
Hutchinson, Mark R. [6 ,7 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Labs Neuroimmunol, Houston, TX 77030 USA
[2] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
[3] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden
[4] Univ Texas Dallas, Ctr Adv Pain Studies, Sch Behav & Brain Sci, Neuroimmunol & Behav Lab, Richardson, TX 75080 USA
[5] Harvard Med Sch, Athinoula A Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02129 USA
[6] Univ Adelaide, Australian Res Council Ctr Excellence Nanoscale B, Adelaide, SA 5005, Australia
[7] Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5005, Australia
来源：
JOURNAL OF NEUROSCIENCE | 2021年 / 41卷 / 05期
基金：
澳大利亚研究理事会; 美国国家卫生研究院; 瑞典研究理事会;
关键词：
sex differences; TSPO; Nrf2; biomarkers; Fc gamma receptors; cannabinoids; PROTEIN; 18; KDA; ANTIBODY-INDUCED ARTHRITIS; DORSAL-ROOT GANGLION; IGG IMMUNE-COMPLEX; SPINAL-CORD; TRANSLOCATOR PROTEIN; NEUROPATHIC PAIN; GLIAL ACTIVATION; ENDOCANNABINOID SYSTEM; CANNABINOID RECEPTORS;
D O I：
10.1523/JNEUROSCI.1650-20.2020
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.
引用
收藏
页码：855 / 865
页数：11
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