Cobalt-Catalyzed Tandem Radical Cyclization/C-C Coupling Initiated by Directed C-H Activation

被引：15

作者：

Sun, Qiao ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 13期

关键词：

SECONDARY ALKYL-HALIDES; UNACTIVATED OLEFINS; BONDS; ARYLATION; DICARBOFUNCTIONALIZATION; IODOALKANES; DERIVATIVES; BENZAMIDES; REAGENTS; STRATEGY;

D O I：

10.1021/acs.orglett.9b01846

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt-N-heterocyclic carbene catalyst promotes a tandem radical cyclization/C-C coupling reaction between tosylamide-tethered bromo-alkenes and aryl N-H imines initiated by chelation-assisted arene C-H activation, affording 3-(arylmethyl)pyrrolidine derivatives in moderate to good yields. The reaction tolerates a variety of substituents on the aryl imine as well as various modifications on the bromoalkene substrate.

引用

页码：5238 / 5242

页数：5

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