Cobalt-Catalyzed Tandem Radical Cyclization/C-C Coupling Initiated by Directed C-H Activation

被引：15
|
作者：
Sun, Qiao [1 ]
Yoshikai, Naohiko [1 ]
机构：
[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 13期
关键词：
SECONDARY ALKYL-HALIDES; UNACTIVATED OLEFINS; BONDS; ARYLATION; DICARBOFUNCTIONALIZATION; IODOALKANES; DERIVATIVES; BENZAMIDES; REAGENTS; STRATEGY;
D O I：
10.1021/acs.orglett.9b01846
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A cobalt-N-heterocyclic carbene catalyst promotes a tandem radical cyclization/C-C coupling reaction between tosylamide-tethered bromo-alkenes and aryl N-H imines initiated by chelation-assisted arene C-H activation, affording 3-(arylmethyl)pyrrolidine derivatives in moderate to good yields. The reaction tolerates a variety of substituents on the aryl imine as well as various modifications on the bromoalkene substrate.
引用
收藏
页码：5238 / 5242
页数：5
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