Hyperbaric oxygen therapy in BKV-associated hemorrhagic cystitis refractory to intravenous and intravesical cidofovir: Case report and review of literature

被引：21

作者：

Focosi, Daniele ^{[1
]}

Maggi, Fabrizio ^{[2
,3
]}

Pistolesi, Donatella ^{[4
]}

Benedetti, Edoardo ^{[1
]}

Papineschi, Federico ^{[1
]}

Galimberti, Sara ^{[1
]}

Ceccherini-Nelli, Luca ^{[2
,3
]}

Petrini, Mario ^{[1
]}

机构：

[1] Univ Pisa, Dept Oncol Transplantat & New Technol Med, Div Hematol, I-56100 Pisa, Italy

[2] Univ Pisa, Virol Sect, I-56100 Pisa, Italy

[3] Univ Pisa, Dept Expt Pathol, Retrovirus Ctr, I-56100 Pisa, Italy

[4] Univ Pisa, Dept Surg, Div Urol, I-56100 Pisa, Italy

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 04期

关键词：

Acute myeloid leukemia; BK virus; BKV; Hemorrhagic cystitis; Allogeneic hematopoietic stem cell transplantation; Hyperbaric oxygen; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANT; VIDARABINE THERAPY; BLADDER INSTILLATION; FORMALIN TREATMENT; RIBAVIRIN THERAPY; ALUMINUM TOXICITY; CMV REACTIVATION; ADENOVIRUS; VIRUS;

D O I：

10.1016/j.leukres.2008.06.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hemorrhagic cystitis is a common complication in hematopoietic stem cell transplant recipients. We report here a case of severe BKV-associated hemorrhagic cystitis who did not respond to intravenous cidofovir. Overt hematuria successfully resolved after a few days on hyperbaric oxygen and intravesical instillations of cidofovir, while BK viruria dropped after a few weeks and remained low. We review the literature for therapeutic options in hemorrhagic cystitis and try to explain how hyperbaric oxygen stimulates mucosal repair in the urinary bladder. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：556 / 560

页数：5

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