The Pivotal Role of Nitric Oxide: Effects on the Nervous and Immune Systems

被引：1

作者：

Banuls, Celia ^{[1
]}

Rocha, Milagros ^{[1
,2
]}

Rovira-Llopis, Susana ^{[1
,2
]}

Falcon, Rosa ^{[1
,2
]}

Castello, Raquel ^{[1
,2
]}

Herance, Jose R. ^{[1
]}

Polo, Miriam ^{[1
,3
,4
]}

Blas-Garcia, Ana ^{[1
,3
,4
]}

Hernandez-Mijares, Antonio ^{[1
,2
,5
]}

Victor, Victor M. ^{[1
,2
,6
]}

机构：

[1] Univ Hosp Doctor Peset, Fdn Invest Sanitaria & Biomed Comunidad Valencian, Valencia 46017, Spain

[2] INCLIVA Fdn, Valencia, Spain

[3] Univ Valencia, Dept Pharmacol, E-46003 Valencia, Spain

[4] Univ Valencia, CIBER Res Grp CB06 04 0071, CIBER Hepat & Digest Dis, E-46003 Valencia, Spain

[5] Univ Valencia, Dept Med, E-46003 Valencia, Spain

[6] Univ Valencia, Dept Physiol, Valencia, Spain

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 29期

关键词：

Nitric oxide; Mitochondria; Immune system; Leukocyte; Nervous system; LEUKOCYTE/ENDOTHELIAL CELL-INTERACTIONS; SYNTHASE MESSENGER-RNA; OXIDATIVE STRESS; S-NITROSYLATION; L-ARGININE; MITOCHONDRIAL DYSFUNCTION; TRYPANOSOMA-CRUZI; T-CELLS; EXPRESSIONAL CONTROL; BIPHASIC REGULATION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nitric oxide (NO) has an important role in physiological and pathological processes in general, and in particular plays a homeostatic role in the nervous and immune systems. The many different physiological functions of NO include those of a mediator of blood vessel dilation, neurotransmitter, neuromodulator and inductor of mitochondrial biogenesis. In addition, NO can transform into highly reactive and harmful molecules producing an impairment of the DNA, lipids or proteins, and thus altering their function. This dual action of NO, by which it plays an important role in homeostasis and aids the development of pathological processes, makes this molecule an interesting target for medical therapies, especially with respect to the nervous and immune systems. This review describes the multiple roles of NO played out in the nervous and immune systems during different physiological and pathophysiological processes.

引用

页码：4679 / 4689

页数：11

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