Synergetic Synthesis and Docking Studies of 1-(2,2-Difluorobenzo[d][1,3]dioxol-6-yl)-N-(6-substitutedpyridin-2-yl)cyclopropanecarboxamide Derivatives

被引：0
|
作者：
Yadaiah, S. [1 ]
Laxminarayana, E. [2 ]
Merugu, Ramchander [3 ]
Jyothi, M. [1 ]
机构：
[1] Mahatma Gandhi Univ, Dept Chem, Nalgonda, Telangana, India
[2] Sreenidhi Inst Sci & Technol Autonomous, Dept Chem, Hyderabad, Telangana, India
[3] Mahatma Gandhi Univ, Dept Bio Chem, Nalgonda, Telangana, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 30卷 / 02期
关键词：
Anti-inflammatory; Cyclopropane carboxamide; Docking studies; Pyridines; SMALL-MOLECULE CORRECTORS; CYSTIC-FIBROSIS; DELTA-F508-CFTR CORRECTORS; POTENT; DISCOVERY; IVACAFTOR;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The present paper describes palladium-catalyzed facile approach for the synthesis of 1-(2,2-difluorobenzo[d][1,3]dioxol-6-yl)-N-(6-phenylpyridin-2-yl)cyclopropanecarboxamide derivatives. The structures of synthesized compounds have been established on the basis of their nuclear magnetic resonance and mass spectral data. Docking studies of the synthesized compounds were performed which demonstrate well anti-inflammatory activity.
引用
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页码：319 / 324
页数：6
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