Skin Testing in the Evaluation and Management of Carboplatin-Related Hypersensitivity Reactions

被引：39
作者：
Lax, Timothy [1 ]
Long, Aidan [1 ]
Banerji, Aleena [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol,Dept Med, Boston, MA USA
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2015年 / 3卷 / 06期
关键词：
Carboplatin; Hypersensitivity reaction; Allergy; Skin testing; Predictive value; Timing; Management; GYNECOLOGIC MALIGNANCIES; RISK STRATIFICATION; COMPLEX SALTS; DESENSITIZATION; CHEMOTHERAPY; ALLERGY; CANCER; CISPLATIN; PLATINUM; PROTOCOL;
D O I：
10.1016/j.jaip.2015.07.003
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Carboplatin-induced hypersensitivity reactions (HSRs) are a frequent occurrence in patients being retreated for malignancy. The most common and severe reactions are thought to be IgE mediated. Currently, skin testing is the only method used clinically to identify individuals sensitized to carboplatin. Despite almost 20 years of clinical use, a standardized approach to skin testing and its use in the management of carboplatin HSRs has not been well established. We review the utility of carboplatin skin testing and discuss factors that influence the interpretation of skin testing results. A risk stratification strategy using skin testing and desensitization to manage patients with carboplatin HSRs is proposed. (C) 2015 American Academy of Allergy, Asthma & Immunology
引用
收藏
页码：856 / 862
页数：7
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