Mast cells in asthma - state of the art

被引：129

作者：

Bradding, P. ^{[1
]}

Arthur, G. ^{[1
]}

机构：

[1] Univ Leicester, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2016年 / 46卷 / 02期

关键词：

AIRWAY SMOOTH-MUSCLE; FC-EPSILON-RI; NECROSIS-FACTOR-ALPHA; BRONCHOALVEOLAR LAVAGE FLUID; THYMIC STROMAL LYMPHOPOIETIN; COLONY-STIMULATING FACTOR; C-KIT RECEPTOR; PLATELET-ACTIVATING-FACTOR; INNATE LYMPHOID-CELLS; ENDOTHELIAL GROWTH-FACTOR;

D O I：

10.1111/cea.12675

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mast cells (MCs) play a central role in tissue homoeostasis, sensing the local environment through numerous innate cell surface receptors. This enables them to respond rapidly to perceived tissue insults with a view to initiating a co-ordinated programme of inflammation and repair. However, when the tissue insult is chronic, the ongoing release of multiple pro-inflammatory mediators, proteases, cytokines and chemokines leads to tissue damage and remodelling. In asthma, there is strong evidence of ongoing MC activation, and their mediators and cell-cell signals are capable of regulating many facets of asthma pathophysiology. This article reviews the evidence behind this.

引用

页码：194 / 263

页数：70

共 739 条

[41] Total and specific IgE in nasal polyps is related to local eosinophilic inflammation [J].

Bachert, C ;

Gevaert, P ;

Holtappels, G ;

Johansson, SGO ;

van Cauwenberge, P .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (04) :607-614

[42] Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma [J].

Bachert, Claus ;

van Steen, Kristel ;

Zhang, Nan ;

Holtappels, Gabriele ;

Cattaert, Tom ;

Maus, Barbel ;

Buhl, Roland ;

Taube, Christian ;

Korn, Stephanie ;

Kowalski, Marek ;

Bousquet, Jean ;

Howarth, Peter .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (02) :376-+

[43] Lysophosphatidic acid accelerates the development of human mast cells [J].

Bagga, S ;

Price, KS ;

Lin, DA ;

Friend, DS ;

Austen, KF ;

Boyce, JA .

BLOOD, 2004, 104 (13) :4080-4087

[44]

Baghestanian M, 1997, BLOOD, V90, P4438

[45] Mast Cell Phenotype, Location, and Activation in Severe Asthma Data from the Severe Asthma Research Program [J].

Balzar, Silvana ;

Fajt, Merritt L. ;

Comhair, Suzy A. A. ;

Erzurum, Serpil C. ;

Bleecker, Eugene ;

Busse, William W. ;

Castro, Mario ;

Gaston, Benjamin ;

Israel, Elliot ;

Schwartz, Lawrence B. ;

Curran-Everett, Douglas ;

Moore, Charity G. ;

Wenzel, Sally E. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (03) :299-309

[46] VENOUS PLASMA HISTAMINE IN EXERCISE-INDUCED AND HYPERVENTILATION-INDUCED ASTHMA IN MAN [J].

BARNES, PJ ;

BROWN, MJ .

CLINICAL SCIENCE, 1981, 61 (02) :159-162

[47] Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma [J].

Barnig, Cindy ;

Cernadas, Manuela ;

Dutile, Stefanie ;

Liu, Xiaoli ;

Perrella, Mark A. ;

Kazani, Shamsah ;

Wechsler, Michael E. ;

Israel, Elliot ;

Levy, Bruce D. .

SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (174)

[48] Chemotaxis and transendothelial migration of CD34+ hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1 [J].

Bautz, F ;

Denzlinger, C ;

Kanz, L ;

Möhle, R .

BLOOD, 2001, 97 (11) :3433-3440

[49] CELLULAR EVENTS IN THE BRONCHI IN MILD ASTHMA AND AFTER BRONCHIAL PROVOCATION [J].

BEASLEY, R ;

ROCHE, WR ;

ROBERTS, JA ;

HOLGATE, ST .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (03) :806-817

[50] EFFECT OF A THROMBOXANE RECEPTOR ANTAGONIST ON PGD2-INDUCED AND ALLERGEN-INDUCED BRONCHOCONSTRICTION [J].

BEASLEY, RCW ;

FEATHERSTONE, RL ;

CHURCH, MK ;

RAFFERTY, P ;

VARLEY, JG ;

HARRIS, A ;

ROBINSON, C ;

HOLGATE, ST .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (04) :1685-1693

← 1 2 3 4 5 6 7 8 9 10 →