Mast cells in asthma - state of the art

被引：129

作者：

Bradding, P. ^{[1
]}

Arthur, G. ^{[1
]}

机构：

[1] Univ Leicester, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2016年 / 46卷 / 02期

关键词：

AIRWAY SMOOTH-MUSCLE; FC-EPSILON-RI; NECROSIS-FACTOR-ALPHA; BRONCHOALVEOLAR LAVAGE FLUID; THYMIC STROMAL LYMPHOPOIETIN; COLONY-STIMULATING FACTOR; C-KIT RECEPTOR; PLATELET-ACTIVATING-FACTOR; INNATE LYMPHOID-CELLS; ENDOTHELIAL GROWTH-FACTOR;

D O I：

10.1111/cea.12675

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Mast cells (MCs) play a central role in tissue homoeostasis, sensing the local environment through numerous innate cell surface receptors. This enables them to respond rapidly to perceived tissue insults with a view to initiating a co-ordinated programme of inflammation and repair. However, when the tissue insult is chronic, the ongoing release of multiple pro-inflammatory mediators, proteases, cytokines and chemokines leads to tissue damage and remodelling. In asthma, there is strong evidence of ongoing MC activation, and their mediators and cell-cell signals are capable of regulating many facets of asthma pathophysiology. This article reviews the evidence behind this.

引用

页码：194 / 263

页数：70

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