Donepezil regulates energy metabolism and favors bone mass accrual

被引：28

作者：

Eimar, Hazem ^{[1
]}

Alebrahim, Sharifa ^{[1
]}

Manickam, Garthiga ^{[1
]}

Al-Subaie, Ahmed ^{[1
]}

Abu-Nada, Lina ^{[1
]}

Murshed, Monzur ^{[1
,2
,3
]}

Tamimi, Faleh ^{[1
]}

机构：

[1] McGill Univ, Fac Dent, Montreal, PQ H3A 0C7, Canada

[2] McGill Univ, Fac Med, Montreal, PQ H3G 1Y6, Canada

[3] Shriners Hosp Children, Genet Unit, Montreal, PQ H3G 1A6, Canada

来源：

BONE | 2016年 / 84卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

Bone; Energy metabolism; Acetylcholinesterase inhibitors; Autonomous nervous system; SYMPATHETIC-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE PATIENTS; WHITE ADIPOSE-TISSUE; LOCOMOTOR-ACTIVITY; HIP FRACTURE; ACETYLCHOLINESTERASE INHIBITORS; PARASYMPATHETIC INNERVATION; CHOLINESTERASE ACTIVITY; HYDROCHLORIDE E2020; INSULIN-SECRETION;

D O I：

10.1016/j.bone.2015.12.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The autonomous nervous system regulates bone mass through the sympathetic and parasympathetic arms. The sympathetic nervous system (SNS) favors bone loss whereas the parasympathetic nervous system (PNS) promotes bone mass accrual. Donepezil, a central-acting cholinergic agonist, has been shown to down-regulate SNS and up-regulate PNS signaling tones. Accordingly, we hypothesize that the use of donepezil could have beneficial effects in regulating bone mass. To test our hypothesis, two groups of healthy female mice were treated either with donepezil or saline. Differences in body metabolism and bone mass of the treated groups were compared. Body and visceral fat weights as well as serum leptin level were increased in donepezil-treated mice compared to control, suggesting that donepezil effects on SNS influenced metabolic activity. Donepezil-treated mice had better bone quality than controls due to a decrease in osteoclasts number. These results indicate that donepezil is able to affect whole body energy metabolism and favors bone mass in young female WT mice. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：131 / 138

页数：8

共 77 条

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