Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder

被引：0

作者：

Shi, Zilu ^{[1
]}

Huang, Qian ^{[2
]}

Chen, Jian ^{[3
]}

Yu, Pengcheng ^{[1
]}

Wang, Xiaosong ^{[1
]}

Qiu, Hong ^{[1
]}

Chen, Yijie ^{[4
]}

Dong, Yangyang ^{[5
]}

机构：

[1] Fujian Med Coll, Hosp Quanzhou 1, Dept Nephrol, 250 East St, Quanzhou City 362000, Fujian Province, Peoples R China

[2] Zhejiang Univ, Dept Physiol, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China

[3] Nanjing Mil Command, Dept Nephrol, Fuzhou Gen Hosp, Fuzhou 350025, Fujian Province, Peoples R China

[4] Fujian Med Coll, Hosp Quanzhou 1, Dept Radiat Oncol, Quanzhou City 362000, Fujian Province, Peoples R China

[5] Fujian Med Coll, Hosp Quanzhou 1, Dept Surg Oncol, Quanzhou City 362000, Fujian Province, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2015年 / 7卷 / 10期

关键词：

Gallbladder cancer; squamous cell carcinoma; adenosquamous carcinoma; HMGB1; prognosis; GLYCATION END-PRODUCTS; MOBILITY GROUP BOX-1; AMPHOTERIN; CANCER; RAGE; RECEPTOR; PROTEIN; CELLS; METASTASIS; GROWTH;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HMGB1 (High mobility group box 1) expressions in adenocarcinoma (AC) and squamous cell/adenosquamous (SC/ASC) carcinoma of gallbladder, as well as its prognostic significance, have not yet been evaluated. We investigated HMGB1 expression in 80 cases of AC gallbladder cancer and 52 cases of SC/ASC gallbladder cancer. Survival information was concomitantly collected. The association of HMGB1 expression with clinicopathological characteristics and the possible prognostic role of HMGB1 for two aforementioned subtypes of gallbladder cancers were also analyzed. siRNA technique was utilized to explore the role of HMGB1 in proliferation and invasion of gallbladder cancer cells in vitro. HMGB1 overexpression is present in AC and SC/ASC gallbladder cancers. HMGB1 expression significantly associates with growth and metastasis of AC and SC/ASC gallbladder cancers. In vitro cell experiments based on siRNA demonstrated that HMGB1 downregulation inhibits proliferation and invasion of gallbladder cancer cells. Kaplan-Meier analysis revealed that HMGB1 expression is negatively associated with overall survival time of patients with AC or SC/ASC gallbladder cancer. Cox multivariate analysis confirmed that HMGB1 is an independent risk factor for survival of patients with AC or SC/ASC gallbladder cancer. HMGB1 overexpression closely correlates with progression and poor prognosis of AC and SC/ASC gallbladder cancers.

引用

页码：2015 / 2025

页数：11

共 39 条

[1] HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis [J].