Copper(I)-Catalyzed Interrupted Click Reaction: Synthesis of Diverse 5-Hetero-Functionalized Triazoles

被引：214

作者：

Wang, Weiguo ^{[1
]}

Peng, Xianglong ^{[1
]}

Wei, Fang ^{[1
]}

Tung, Chen-Ho ^{[1
]}

Xu, Zhenghu ^{[1
,2
]}

机构：

[1] Shandong Univ, Dept Chem, Educ Minist, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 02期

关键词：

aminations; click reactions; sulfenylation; triazoles; AZIDE-ALKYNE CYCLOADDITION; COPPER-CATALYZED CYCLOADDITION; C-H SULFENYLATION; ONE-POT REACTION; ENANTIOSELECTIVE SYNTHESIS; REGIOSELECTIVE SYNTHESIS; ORGANIC AZIDES; N-TOSYLHYDRAZONES; STRATEGY; 1,2,3-TRIAZOLES;

D O I：

10.1002/anie.201509124

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 5-heterofunctionalized triazoles are important scaffolds in bioactive compounds, but current click reactions (CuAAC) cannot produce these core structures. A copper(I)-catalyzed interrupted click reaction to access diverse 5-functionalized triazoles is reported. Various 5-amino-, thio-, and selenotriazoles were readily assembled in one step in high yields. The reaction proceeds under mild conditions with complete regioselectivity. It also features a broad substrate scope and good functional group compatibility.

引用

页码：649 / 653

页数：5

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