Prenatal lead exposure and cord blood DNA methylation in PROGRESS: an epigenome-wide association study

被引:10
作者
Heiss, Jonathan A. [1 ]
Tellez-Rojo, Martha M. [2 ]
Estrada-Gutierrez, Guadalupe [3 ]
Schnaas, Lourdes [3 ]
Amarasiriwardena, Chitra [1 ]
Baccarelli, Andrea A. [4 ]
Wright, Robert O. [1 ]
Just, Allan C. [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, One Gustave L Levy Pl,Box 1057, New York, NY 10029 USA
[2] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Univ 655 Colonia Santa Maria Ahuacatitlan, Cuernavaca, Morelos, Mexico
[3] Natl Inst Perinatol, Calle Montes Urales 800, Mexico City, DF, Mexico
[4] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Med Ctr, 722 West 168th St, New York, NY USA
来源
ENVIRONMENTAL EPIGENETICS | 2020年 / 6卷 / 01期
基金
美国国家卫生研究院;
关键词
DNA methylation; prenatal lead exposure; cord blood; PROGRESS Study; Infinium EPIC; X-RAY-FLUORESCENCE; US CHILDREN; BONE LEAD; PREGNANCY;
D O I
10.1093/eep/dvaa014
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The effects of prenatal lead exposure on child development include impaired growth and cognitive function. DNA methylation might be involved in the underlying mechanisms and previous epigenome-wide association studies reported associations between lead exposure during pregnancy and cord blood methylation levels. However, it is unclear during which developmental stage lead exposure is most harmful. Cord blood methylation levels were assayed in 420 children from a Mexican pre-birth cohort using the Illumina Infinium MethylationEPIC microarray. Lead concentrations were measured in umbilical cord blood as well as in blood samples from the mothers collected at 2nd and 3rd trimester and delivery using inductively coupled plasma-mass spectrometry. In addition, maternal bone lead levels were measured in tibia and patella using X-ray fluorescence. Comprehensive quality control and preprocessing of microarray data was followed by an unbiased restriction to methylation sites with substantial variance. Methylation levels at 202 111 cytosine-phosphate-guanine sites were regressed on each exposure adjusting for child sex, leukocyte composition, batch variables, gestational age, birthweight-for-gestational-age, maternal age, maternal education and mode of delivery. We find no association between prenatal lead exposure and cord blood methylation. This null result is strengthened by a sensitivity analysis showing that in the same dataset known biomarkers for birthweight-for-gestational-age can be recovered and the fact that phenotypic associations with lead exposure have been described in the same cohort.
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页数:7
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