Circulating tumor cell profiling for precision oncology

被引：50
作者：
Labib, Mahmoud [1 ]
Kelley, Shana O. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Toronto, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada
[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada
[3] Univ Toronto, Dept Biochem, Toronto, ON, Canada
[4] Univ Toronto, Dept Chem, Toronto, ON, Canada
来源：
MOLECULAR ONCOLOGY | 2021年 / 15卷 / 06期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会; 美国国家卫生研究院;
关键词：
CTC enrichment; drug selection; microfluidics; molecular profiling; precision oncology; tumor resistance;
D O I：
10.1002/1878-0261.12901
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Analysis of circulating tumor cells (CTCs) collected from patient's blood offers a broad range of opportunities in the field of precision oncology. With new advances in profiling technology, it is now possible to demonstrate an association between the molecular profiles of CTCs and tumor response to therapy. In this Review, we discuss mechanisms of tumor resistance to therapy and their link to phenotypic and genotypic properties of CTCs. We summarize key technologies used to isolate and analyze CTCs and discuss recent clinical studies that examined CTCs for genomic and proteomic predictors of responsiveness to therapy. We also point out current limitations that still hamper the implementation of CTCs into clinical practice. We finally reflect on how these shortcomings can be addressed with the likely contribution of multiparametric approaches and advanced data analytics.
引用
收藏
页码：1622 / 1646
页数：25
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