Perivascular dendritic cells of the human dental pulp

被引:38
|
作者
Okiji, T
Jontell, M
Belichenko, P
Bergenholtz, G
Dahlstrom, A
机构
[1] GOTHENBURG UNIV,FAC ODONTOL,DEPT ENDODONTOL & ORAL DIAGNOSIS,S-41390 GOTHENBURG,SWEDEN
[2] UNIV GOTHENBURG,INST NEUROBIOL,DEPT ANAT & CELL BIOL,GOTHENBURG,SWEDEN
[3] TOKYO MED & DENT UNIV,DEPT ENDODONT,TOKYO 113,JAPAN
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1997年 / 159卷 / 02期
关键词
CD68; confocal laser scanning microscopy; dendritic cell; endothelial cell; factor XIIIa; HLA-DR; human dental pulp; immunohistochemistry;
D O I
10.1046/j.1365-201X.1997.584337000.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The morphological and phenotypical features of the class it molecule (HLA-DR) expressing cells in human dental pulps were compared with those of previously characterized perivascular dendritic cells in the dermis. We have further investigated how these pulpal cells are structurally related to the vascular system. Double-immunofluorescence staining revealed that a substantial portion of the pulpal HLA-DR expressing cells also expressed factor XIIIa, a marker for dendritic cells. The cells usually had a highly dendritic appearance and formed a reticular network in the pulpal connective tissue. The majority of cells also expressed macrophage-related antigens (CD14 and CD68). A small but distinct population of pulpal cells. representing approximately 13% of the class II molecule expressing cells. was devoid of a typical macrophage phenotype. This subpopulation oi pulpal cells may be similar to dendritic cells present in the dermis. Confocal laser scanning microscopy showed that highly dendritic cells. found in close relation to the endothelium. had dendritic processes which were found to be in contact with the peripheral cell membrane of the endothelial cells. These cells formed a three-dimensional structure around the microvessel resembling a cellular conduit. We conclude that the human dental pulp is equipped with class ii molecule-expressing perivascular dendritic cells composed of a heterogeneous cell population.
引用
收藏
页码:163 / 169
页数:7
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