The expression of fibroblast growth factor receptor-3 in synovial osteochondromatosis of the temporomandibular joint

被引：17

作者：

Tojyo, I ^{[1
]}

Yamaguti, A ^{[1
]}

Ozaki, H ^{[1
]}

Yoshida, H ^{[1
]}

Fujita, S ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Oral & Maxillofacial Surg, Wakayama 6418509, Japan

来源：

ARCHIVES OF ORAL BIOLOGY | 2004年 / 49卷 / 07期

关键词：

synovial osteochondromatosis; temporomandibular joint; fibrobtast growth factor receptor-3; immunohistochemistry; reverse transcription-polymerase chain; reaction;

D O I：

10.1016/j.archoralbio.2003.12.009

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Primary synovial. osteochondromatosis (PSC) is a disease of unknown aetiology. It was reported recently that expression of fibrobtast growth factor receptor-3 (FGFR-3) was observed specifically in PSC. We classified six cases of synovial osteochondromatosis (SC) of the temporomandibular joint (TMJ) into two types of SC, PSC (five cases) and secondary synovial. osteochondromatosis (SSC) (one case), by means of clinical findings and haematoxylin and eosin stain. The five PSC cases were classified into three different phases according to Milgram's classification. Immunohistochemical staining of FGFR-3 was carried out for each SC case, along with specimens of internal derangement (ID) of the TMJ, and normal. articular disc and synovial. membrane. FGFR-3 was found in all three phases of PSC, but not in SSC, ID or normal TMJ. Moreover, in a comparison between cultured synovial. cells of PSC (Phase III) and ID, reverse transcription-polymerase chain reaction reveated a stronger positive reaction in PSC. These results indicate that the synovial. membrane in Phase III PSC can produce cartilage nodules, as in Phases I and II. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：591 / 594

页数：4

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